PMID- 23653377
OWN - NLM
STAT- MEDLINE
DCOM- 20140606
LR  - 20220408
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 29
IP  - 7
DP  - 2013 Oct
TI  - Circulating secreted frizzled-related protein 5 (Sfrp5) and wingless-type MMTV 
      integration site family member 5a (Wnt5a) levels in patients with type 2 diabetes 
      mellitus.
PG  - 551-6
LID - 10.1002/dmrr.2426 [doi]
AB  - BACKGROUND: Secreted frizzled-related protein 5 (Sfrp5), an endogenous inhibitor 
      of wingless-type MMTV integration site family (Wnt) signalling, is an 
      anti-inflammatory adipokine whose expression is perturbed in models of obesity 
      and type 2 diabetes mellitus (T2DM). Wnt member 5a (Wnt5a) is a representative 
      ligand, and recent reports suggest that Wnt5a is involved in inflammatory 
      diseases and metabolic disorders. The aim of this study was to investigate 
      whether plasma Wnt5a and Sfrp5 levels are altered in patients with T2DM. METHODS: 
      Plasma Sfrp5 and Wnt5a concentrations were measured through enzyme-linked 
      immunosorbent assay in type 2 diabetic and nondiabetic subjects. RESULTS: A total 
      of 82 patients with T2DM and 42 nondiabetic subjects were studied. Plasma Sfrp5 
      levels were found to be elevated in patients with T2DM (9.4 +/- 9.0 vs 7.4 +/- 10.9 
      ng/mL, p = 0.006). In contrast, Wnt5a levels were decreased (6.8 +/- 12.6 vs 9.1 +/- 
      4.0 ng/dL, p < 0.001). Increasing concentrations of Sfrp5 were independently and 
      significantly associated with T2DM. Multiple logistic regression analysis 
      revealed Sfrp5 as an independent association factor for T2DM, even after full 
      adjustment of known biomarkers. In a multiple linear regression analysis, only 
      the fasting glucose level was positively associated with the plasma Sfrp5 level. 
      CONCLUSIONS: Our results indicate that Sfrp5 may play a role in the pathogenesis 
      of T2DM.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Lu, Yung-Chuan
AU  - Lu YC
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da 
      Hospital, I-Shou University, Kaohsiung, Taiwan; Department of Medical Nutrition, 
      Institute of Biotechnology and Chemical Engineering, I-Shou University, 
      Kaohsiung, Taiwan.
FAU - Wang, Chao-Ping
AU  - Wang CP
FAU - Hsu, Chia-Chang
AU  - Hsu CC
FAU - Chiu, Cheng-An
AU  - Chiu CA
FAU - Yu, Teng-Hung
AU  - Yu TH
FAU - Hung, Wei-Chin
AU  - Hung WC
FAU - Lu, Li-Fen
AU  - Lu LF
FAU - Chung, Fu-Mei
AU  - Chung FM
FAU - Tsai, I-Ting
AU  - Tsai IT
FAU - Lin, Hsien-Chang
AU  - Lin HC
FAU - Lee, Yau-Jiunn
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Biomarkers)
RN  - 0 (Eye Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (SFRP5 protein, human)
RN  - 0 (WNT5A protein, human)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt-5a Protein)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/etiology
MH  - Eye Proteins/*blood/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Membrane Proteins/*blood/physiology
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Proto-Oncogene Proteins/*blood
MH  - Wnt Proteins/*blood
MH  - Wnt-5a Protein
OTO - NOTNLM
OT  - Wnt5a
OT  - anti-inflammatory
OT  - secreted frizzled-related protein 5
OT  - type 2 diabetes mellitus
EDAT- 2013/05/09 06:00
MHDA- 2014/06/07 06:00
CRDT- 2013/05/09 06:00
PHST- 2012/11/27 00:00 [received]
PHST- 2013/03/25 00:00 [revised]
PHST- 2013/04/23 00:00 [accepted]
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2014/06/07 06:00 [medline]
AID - 10.1002/dmrr.2426 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2013 Oct;29(7):551-6. doi: 10.1002/dmrr.2426.