PMID- 23653426
OWN - NLM
STAT- MEDLINE
DCOM- 20131218
LR  - 20181202
IS  - 1099-1077 (Electronic)
IS  - 0885-6222 (Linking)
VI  - 28
IP  - 3
DP  - 2013 May
TI  - Acute mood effect of donepezil in young, healthy volunteers.
PG  - 263-9
LID - 10.1002/hup.2319 [doi]
AB  - OBJECTIVE: Chronic use of the acetylcholinesterase inhibitor donepezil has been 
      found to improve mood or to induce mania/hypomania in many neuropsychiatric 
      patients with altered cholinergic and dopaminergic tone. Our aim was to determine 
      whether acutely administered donepezil would alter mood in volunteers with no 
      such alterations. METHODS: This investigation was a double-blind, crossover 
      design study of 15 young, healthy male participants who were allocated in random 
      order to three oral treatments: placebo and 5-mg and 7.5-mg donepezil (doses 
      which exert clinical and acute cognitive effects without considerable peripheral 
      side effects). At the theoretical peak-plasma concentrations of donepezil, 
      volunteers rated how they felt on validated questionnaires, which included 
      various dimensions of subjective feelings. We also assessed changes in 
      brain-derived neurotrophic factor (BDNF), which is increased by donepezil after 
      chronic regimes and is related to modulation of mood. RESULTS: Donepezil 
      significantly increased ratings of vigour and anxiety symptoms (medium effect 
      sizes). No changes in bodily symptoms or BDNF were observed. CONCLUSIONS: Acute 
      donepezil administration in participants with unaltered cholinergic and 
      dopaminergic tone led to positive and negative changes in affect. These results 
      call for further research on the direct mood effects of donepezil.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Pompeia, Sabine
AU  - Pompeia S
AD  - Departamento de Psicobiologia, Universidade Federal de Sao Paulo (UNIFESP), Sao 
      Paulo, Brazil. spompeia@gmail.com
FAU - Gouveia, Juliana Ramos
AU  - Gouveia JR
FAU - Galduroz, Jose Carlos Fernandes
AU  - Galduroz JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130508
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Indans)
RN  - 0 (Piperidines)
RN  - 8SSC91326P (Donepezil)
SB  - IM
MH  - Adult
MH  - Affect/*drug effects
MH  - Anxiety/prevention & control
MH  - Brain-Derived Neurotrophic Factor/*drug effects/metabolism
MH  - Cholinesterase Inhibitors/administration & dosage/pharmacokinetics/*pharmacology
MH  - Cross-Over Studies
MH  - Donepezil
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Humans
MH  - Indans/administration & dosage/pharmacokinetics/*pharmacology
MH  - Male
MH  - Piperidines/administration & dosage/pharmacokinetics/*pharmacology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2013/05/09 06:00
MHDA- 2013/12/19 06:00
CRDT- 2013/05/09 06:00
PHST- 2012/09/14 00:00 [received]
PHST- 2013/03/20 00:00 [accepted]
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2013/12/19 06:00 [medline]
AID - 10.1002/hup.2319 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2013 May;28(3):263-9. doi: 10.1002/hup.2319. Epub 2013 May 
      8.