PMID- 23653857
OWN - NLM
STAT- MEDLINE
DCOM- 20130726
LR  - 20220317
IS  - 2090-0716 (Electronic)
IS  - 2090-0708 (Print)
IS  - 2090-0708 (Linking)
VI  - 2013
DP  - 2013
TI  - Adipose tissue dysfunction in nascent metabolic syndrome.
PG  - 393192
LID - 10.1155/2013/393192 [doi]
LID - 393192
AB  - The metabolic syndrome (MetS) confers an increased risk for both type 2 diabetes 
      mellitus (T2DM) and cardiovascular disease (CVD). Moreover, studies on adipose 
      tissue biology in nascent MetS uncomplicated by T2DM and/or CVD are scanty. 
      Recently, we demonstrated that adipose tissue dysregulation and aberrant 
      adipokine secretion contribute towards the syndrome's low-grade chronic 
      proinflammatory state and insulin resistance. Specifically, we have made the 
      novel observation that subcutaneous adipose tissue (SAT) in subjects with nascent 
      MetS has increased macrophage recruitment with cardinal crown-like structures. We 
      have also shown that subjects with nascent MetS have increased the levels of 
      SAT-secreted adipokines (IL-1, IL-6, IL-8, leptin, RBP-4, CRP, SAA, PAI-1, MCP-1, 
      and chemerin) and plasma adipokines (IL-1, IL-6, leptin, RBP-4, CRP, SAA, and 
      chemerin), as well as decreased levels of plasma adiponectin and both plasma and 
      SAT omentin-1. The majority of these abnormalities persisted following correction 
      for increased adiposity. Our data, as well as data from other investigators, 
      thus, highlight the importance of subcutaneous adipose tissue dysfunction in 
      subjects with MetS and its contribution to the proinflammatory state and insulin 
      resistance. This adipokine profile may contribute to increased insulin resistance 
      and low-grade inflammation, promoting the increased risk of T2DM and CVD.
FAU - Bremer, Andrew A
AU  - Bremer AA
AD  - Department of Pediatrics, Vanderbilt University, Nashville, TN 37232-9170, USA.
FAU - Jialal, Ishwarlal
AU  - Jialal I
LA  - eng
GR  - KL2 RR024144/RR/NCRR NIH HHS/United States
GR  - UL1 RR024146/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130404
PL  - United States
TA  - J Obes
JT  - Journal of obesity
JID - 101526295
RN  - 0 (Adipokines)
SB  - IM
MH  - Adipokines/blood/metabolism
MH  - Adipose Tissue/*physiopathology
MH  - Cardiovascular Diseases
MH  - Diabetes Mellitus, Type 2
MH  - Humans
MH  - Inflammation
MH  - Insulin Resistance
MH  - Metabolic Syndrome/*physiopathology
MH  - Subcutaneous Fat/physiopathology
PMC - PMC3638696
EDAT- 2013/05/09 06:00
MHDA- 2013/07/28 06:00
PMCR- 2013/04/04
CRDT- 2013/05/09 06:00
PHST- 2013/01/26 00:00 [received]
PHST- 2013/02/14 00:00 [accepted]
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2013/07/28 06:00 [medline]
PHST- 2013/04/04 00:00 [pmc-release]
AID - 10.1155/2013/393192 [doi]
PST - ppublish
SO  - J Obes. 2013;2013:393192. doi: 10.1155/2013/393192. Epub 2013 Apr 4.