PMID- 23654315
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20220317
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 33
IP  - 4
DP  - 2013 May
TI  - Brain-derived neurotrophic factor and ciliary neurotrophic factor in maternal 
      plasma and umbilical cord blood from pre-eclamptic and physiological pregnancies.
PG  - 359-63
LID - 10.3109/01443615.2013.776026 [doi]
AB  - The aim of the study was to investigate the circulating levels of ciliary 
      neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) in 
      maternal serum and umbilical cord blood from respective pregnancies in 
      pre-eclampsia (PE) cases and a control cohort. A total of 12 pre-eclampsia cases 
      and 34 healthy controls were enrolled and the maternal peripheral blood - 
      umbilical cord blood duos, were examined for BDNF and CNTF levels. BNDF levels 
      were significantly higher in umbilical cord blood from pre-eclamptic pregnancies; 
      there was also significant difference between maternal plasma and umbilical cord 
      blood levels of BDNF (p < 0.001) in the controls. The CNTF levels in umbilical 
      cord blood (CNTF-UCB) were significantly higher in PE cases than in the controls 
      (p = 0.03). Significant differences were observed in expression of BDNF and CNTF 
      proteins in maternal peripheral blood and umbilical cord blood between 
      pre-eclampsia cases and healthy controls.
FAU - Bienertova-Vasku, J
AU  - Bienertova-Vasku J
AD  - Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 
      Brno, Czech Republic. jbienert@med.muni.cz
FAU - Bienert, P
AU  - Bienert P
FAU - Zlamal, F
AU  - Zlamal F
FAU - Splichal, Z
AU  - Splichal Z
FAU - Tomandl, J
AU  - Tomandl J
FAU - Tomandlova, M
AU  - Tomandlova M
FAU - Hodicka, Z
AU  - Hodicka Z
FAU - Ventruba, P
AU  - Ventruba P
FAU - Vasku, A
AU  - Vasku A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of 
      Obstetrics and Gynaecology
JID - 8309140
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Ciliary Neurotrophic Factor/*blood
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Gestational Age
MH  - Humans
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Young Adult
EDAT- 2013/05/10 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/05/10 06:00
PHST- 2013/05/10 06:00 [entrez]
PHST- 2013/05/10 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - 10.3109/01443615.2013.776026 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2013 May;33(4):359-63. doi: 10.3109/01443615.2013.776026.