PMID- 23656171
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20130509
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 91
IP  - 5
DP  - 2013 May
TI  - Beneficial effect of flax seeds in streptozotocin (STZ) induced diabetic mice: 
      isolation of active fraction having islet regenerative and glucosidase inhibitory 
      properties.
PG  - 325-31
LID - 10.1139/cjpp-2011-0428 [doi]
AB  - Diabetes mellitus is a metabolic disorder that affects millions of people 
      worldwide. Present study highlights the antidiabetogenic property of Linum 
      usitassimum active fraction (LU6) in streptozotocin (STZ) induced diabetic Swiss 
      mice. Treatment with LU6 fraction showed improved glucose utilization with 
      increase in liver glucose-6-phosphate dehydrogenase enzyme activity and normal 
      glycogenesis in hepatic and muscle tissues. Reduction in pancreatic and 
      intestinal glucosidase inhibitory activity was observed with LU6 treatment, 
      indicating beneficial effects in reducing postprandial hyperglycemia (PPHG). 
      Normalization of plasma insulin and C-peptide levels were observed in diabetic 
      mice, indicating endogenous insulin secretion after the treatment with LU6. The 
      histochemical and immunohistochemical analysis on pancreatic islets suggests the 
      role of LU6 fraction in islet regeneration and insulin secretion as evident in 
      increase functional pancreatic islets producing insulin. Furthermore, significant 
      insulin producing islet formation was also observed in in vitro PANC-1 cells 
      after LU6 treatment, indicating the cellular aggregates to be newly formed 
      islets. This suggests the potential of LU6 fraction in the formation of new 
      islets in vitro, as well as in vivo. Thus, LU6 can be used as a 
      neutraceutical-based first-line treatment for diabetes.
FAU - Dusane, Menakshi Bhat
AU  - Dusane MB
AD  - Biometry and Nutrition Division, Agharkar Research Institute, G.G. Agharkar Road, 
      Pune 411 004, India.
FAU - Joshi, Bimba N
AU  - Joshi BN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130116
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (C-Peptide)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 3.2.1.- (Glucosidases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - C-Peptide/metabolism
MH  - Diabetes Mellitus, Experimental/chemically induced/*drug therapy/metabolism
MH  - Flax/*chemistry
MH  - Glucose/metabolism
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Glucosidases/*antagonists & inhibitors/metabolism
MH  - Hyperglycemia/drug therapy/metabolism
MH  - Hypoglycemic Agents/*chemistry/*pharmacology
MH  - Insulin/metabolism
MH  - Islets of Langerhans/*drug effects/metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Phytotherapy
MH  - Regeneration/*drug effects
EDAT- 2013/05/10 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/05/10 06:00
PHST- 2013/05/10 06:00 [entrez]
PHST- 2013/05/10 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1139/cjpp-2011-0428 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2013 May;91(5):325-31. doi: 10.1139/cjpp-2011-0428. Epub 
      2013 Jan 16.