PMID- 23656829
OWN - NLM
STAT- MEDLINE
DCOM- 20140415
LR  - 20231104
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 11
DP  - 2013 May 8
TI  - The development and validation of the major life changing decision profile 
      (MLCDP).
PG  - 78
LID - 10.1186/1477-7525-11-78 [doi]
AB  - BACKGROUND: Chronic diseases may influence patients taking major life changing 
      decisions (MLCDs) concerning for example education, career, relationships, having 
      children and retirement. A validated measure is needed to evaluate the impact of 
      chronic diseases on MLCDs, improving assessment of their life-long burden. The 
      aims of this study were to develop a validated questionnaire, the "Major Life 
      Changing Decision Profile" (MLCDP) and to evaluate its psychometric properties. 
      METHODS: 50 interviews with dermatology patients and 258 questionnaires, 
      completed by cardiology, rheumatology, nephrology, diabetes and respiratory 
      disorder patients, were analysed for qualitative data using Nvivo8 software. 
      Content validation was carried out by a panel of experts. The first version of 
      the MLCDP was completed by 210 patients and an iterative process of multiple 
      Exploratory Factor Analyses and item prevalence was used to guide item reduction. 
      Face validity and practicability was assessed by patients. RESULTS: 48 MLCDs were 
      selected from analysis of the transcripts and questionnaires for the first 
      version of the MLCDP, and reduced to 45 by combination of similar themes. There 
      was a high intraclass correlation coefficient (0.7) between the 13 members of the 
      content validation panel. Four more items were deleted leaving a 41-item MLCDP 
      that was completed by 210 patients. The most frequently recorded MLCDs were 
      decisions to change eating habits (71.4%), to change smoking/drinking alcohol 
      habits (58.5%) and not to travel or go for holidays abroad (50.9%).Factor 
      analysis suggested item number reduction from 41 to 34, to 29, then 23 items. 
      However after taking into account item prevalence data as well as factor analysis 
      results, 32 items were retained. The 32-item MLCDP has five domains education (3 
      items), job/career (9), family/relationships (5), social (10) and physical (5). 
      The MLCDP score is expressed as the absolute number of decisions that have been 
      affected. CONCLUSIONS: The 32-item (5 domains) MLCDP has been developed as an 
      easy to complete generic tool for use in clinical practice and for quality of 
      life and epidemiological research. Further validation is required.
FAU - Bhatti, Zaheer U
AU  - Bhatti ZU
AD  - Centre for Socioeconomic Research, Cardiff School of Pharmacy and Pharmaceutical 
      Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff 
      CF10 3NB, UK. drzaheer121@hotmail.com
FAU - Salek, Sam S
AU  - Salek SS
FAU - Bolton, Charlotte E
AU  - Bolton CE
FAU - George, Lindsay
AU  - George L
FAU - Halcox, Julian P
AU  - Halcox JP
FAU - Jones, Sharon M
AU  - Jones SM
FAU - Ketchell, Ian R
AU  - Ketchell IR
FAU - Moore, Richard H
AU  - Moore RH
FAU - Sabit, Ramsey
AU  - Sabit R
FAU - Piguet, Vincent
AU  - Piguet V
FAU - Finlay, Andrew Y
AU  - Finlay AY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20130508
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease/*psychology
MH  - Cross-Sectional Studies
MH  - *Decision Making
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - *Life Change Events
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Psychometrics/*standards
MH  - Reproducibility of Results
MH  - Socioeconomic Factors
MH  - *Surveys and Questionnaires
MH  - Wales
MH  - Young Adult
PMC - PMC3702443
EDAT- 2013/05/10 06:00
MHDA- 2014/04/16 06:00
PMCR- 2013/05/08
CRDT- 2013/05/10 06:00
PHST- 2012/10/03 00:00 [received]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/05/10 06:00 [entrez]
PHST- 2013/05/10 06:00 [pubmed]
PHST- 2014/04/16 06:00 [medline]
PHST- 2013/05/08 00:00 [pmc-release]
AID - 1477-7525-11-78 [pii]
AID - 10.1186/1477-7525-11-78 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2013 May 8;11:78. doi: 10.1186/1477-7525-11-78.