PMID- 23656848
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20220318
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Print)
IS  - 0160-6689 (Linking)
VI  - 74
IP  - 4
DP  - 2013 Apr
TI  - Bupropion for overweight women with binge-eating disorder: a randomized, 
      double-blind, placebo-controlled trial.
PG  - 400-6
LID - 10.4088/JCP.12m08071 [doi]
AB  - BACKGROUND: Binge-eating disorder (BED) is defined by recurrent binge eating 
      (eating unusually large quantities of food during which a subjective loss of 
      control is experienced), marked distress about the binge eating, and the absence 
      of inappropriate weight compensatory behaviors. BED is strongly associated with 
      excess weight, and many available psychological and pharmacologic approaches fail 
      to produce much weight loss. The objective of this study was to perform a 
      randomized placebo-controlled trial to evaluate the short-term efficacy of 
      bupropion for the treatment of BED in overweight and obese women. METHOD: 
      Sixty-one overweight and obese (mean body mass index [BMI] = 35.8) women who met 
      DSM-IV-TR research criteria for BED were randomly assigned to receive bupropion 
      (300 mg/d) or placebo for 8 weeks. Participants were enrolled from November 2006 
      to December 2010. No dietary or lifestyle intervention was given. Primary outcome 
      measures were binge-eating frequency and percent BMI loss. Secondary outcome 
      measures were dimensional measures of eating disorder psychopathology, food 
      craving, and depression levels. RESULTS: Eighty-nine percent (n = 54) of 
      randomized participants completed the trial, without differential dropout between 
      the bupropion and placebo groups. Mixed-effects analyses revealed significant 
      time effects for all outcomes but no significant differences between bupropion 
      and placebo on any outcome measure except for weight loss. Participants taking 
      bupropion lost significantly more weight (1.8% vs 0.6% BMI loss; F = 10.57, P = 
      .002). CONCLUSIONS: Bupropion was well tolerated and produced significantly 
      greater-albeit quite modest-short-term weight loss in overweight and obese women 
      with BED. Bupropion did not improve binge eating, food craving, or associated 
      eating disorder features or depression relative to placebo. Our findings do not 
      support bupropion as a stand-alone treatment for BED. The preliminary findings 
      regarding short-term weight losses suggest the need for larger and longer-term 
      trials to evaluate the potential utility of bupropion for enhancing outcomes of 
      psychological interventions that have demonstrated effectiveness for BED but fail 
      to produce weight loss. TRIAL REGISTRATION: ClinicalTrials.gov identifier: 
      NCT00414167
CI  - (c) Copyright 2013 Physicians Postgraduate Press, Inc.
FAU - White, Marney A
AU  - White MA
AD  - Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, PO 
      Box 208098, New Haven, CT 06520, USA. marney.white@yale.edu
FAU - Grilo, Carlos M
AU  - Grilo CM
LA  - eng
SI  - ClinicalTrials.gov/NCT00414167
GR  - K23 DK071646/DK/NIDDK NIH HHS/United States
GR  - K24 DK070052/DK/NIDDK NIH HHS/United States
GR  - R03 DK081404/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 01ZG3TPX31 (Bupropion)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Bulimia/*drug therapy
MH  - Bupropion/*administration & dosage/adverse effects
MH  - Dopamine Uptake Inhibitors/*administration & dosage/adverse effects
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Obesity/drug therapy
MH  - Overweight/*drug therapy
MH  - Treatment Outcome
MH  - Weight Loss/drug effects
PMC - PMC4021866
MID - NIHMS575117
EDAT- 2013/05/10 06:00
MHDA- 2013/07/03 06:00
PMCR- 2014/05/15
CRDT- 2013/05/10 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2013/05/10 06:00 [entrez]
PHST- 2013/05/10 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PHST- 2014/05/15 00:00 [pmc-release]
AID - 10.4088/JCP.12m08071 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2013 Apr;74(4):400-6. doi: 10.4088/JCP.12m08071.