PMID- 23659115
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20180404
IS  - 0042-8817 (Print)
IS  - 0042-8817 (Linking)
VI  - 77
IP  - 1
DP  - 2013
TI  - Characteristics of medulloblastoma in children under age of three years.
PG  - 3-10; discussion 11
AB  - We present a series of 51 medulloblastoma in children under three years, 
      collected in N.N. Burdenko Neurosurgical Institute from 2000 to 2010. 57% of the 
      tumors showed desmoplastic/nodular histology. Performed fluorescence in situ 
      hybridization (FISH) analysis revealed the MYC oncogene amplification in 4%, the 
      MYCN oncogene amplification - in 8%, isochromosome 17q - in 16% of cases. 9q 
      deletion was found in 8% of desmoplastic/ nodular medulloblastomas. Our results 
      showed that desmoplastic/nodular medulloblastoma has a positive predictive value 
      for progression-free survival. Another feature of a biology of medulloblastomas 
      in children younger than three years is the lack of nuclear accumulation of 
      beta-catenin, and 6q deletion. Medulloblastomas with MYCN oncogene amplification 
      often exhibit desmoplastic/nodular histology and a relatively favorable outcome. 
      The most unfavorable prognostic marker is the MYC oncogene amplification, which 
      in our series of 100% combined with the large cell/anaplastic medulloblastoma and 
      isochromosome 17q - such tumors should be included in the "high risk" protocol.
FAU - Ryzhova, M V
AU  - Ryzhova MV
FAU - Zheludkova, O G
AU  - Zheludkova OG
FAU - Kumirova, E V
AU  - Kumirova EV
FAU - Shishkina, L V
AU  - Shishkina LV
FAU - Panina, T N
AU  - Panina TN
FAU - Gorelyshev, S K
AU  - Gorelyshev SK
FAU - Khukhlaeva, E A
AU  - Khukhlaeva EA
FAU - Mazerkina, N A
AU  - Mazerkina NA
FAU - Matuev, K B
AU  - Matuev KB
FAU - Medvedeva, O A
AU  - Medvedeva OA
FAU - Tarasova, E M
AU  - Tarasova EM
FAU - Kholodov, B V
AU  - Kholodov BV
FAU - Kapitul'skaia, O Iu
AU  - Kapitul'skaia OIu
LA  - eng
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Vopr Neirokhir Im N N Burdenko
JT  - Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
JID - 7809757
RN  - 0 (MYCN protein, human)
RN  - 0 (N-Myc Proto-Oncogene Protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Cerebellar Neoplasms/*genetics/mortality/*pathology/surgery
MH  - Child, Preschool
MH  - Chromosome Aberrations/statistics & numerical data
MH  - Female
MH  - Genes, myc/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Medulloblastoma/*genetics/mortality/*pathology/surgery
MH  - N-Myc Proto-Oncogene Protein
MH  - Nuclear Proteins/biosynthesis
MH  - Oncogene Proteins/biosynthesis
EDAT- 2013/05/11 06:00
MHDA- 2013/06/26 06:00
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
PST - ppublish
SO  - Zh Vopr Neirokhir Im N N Burdenko. 2013;77(1):3-10; discussion 11.