PMID- 23660113
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20210315
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 375
IP  - 1-2
DP  - 2013 Aug 15
TI  - The polymorphism in the let-7 targeted region of the Lin28 gene is associated 
      with increased risk of type 2 diabetes mellitus.
PG  - 53-7
LID - S0303-7207(13)00199-8 [pii]
LID - 10.1016/j.mce.2013.04.022 [doi]
AB  - Genetic polymorphisms in the miRNAs pathway of the pathogenesis of disease might 
      contribute to the risk of disease. However, it is unclear whether these 
      polymorphisms about miRNAs are associated with the risk of type 2 diabetes 
      mellitus (T2DM). We performed a case-control study to investigate two 
      polymorphisms in the let-7/Lin28 pathway based on 588 T2DM patients and 588 age 
      and sex matched controls. The results showed that the rs3811463 polymorphism was 
      associated with increased risk of T2DM (odds ratio (OR)=1.47, 95% confidence 
      inference (95%CI)=1.13-1.93, P=0.005), while the rs3811464 not (OR=1.04, 
      95%CI=0.79-1.36, P=0.78). For the rs3811463 polymorphism, the variant genotypes 
      were associated with increased risk of disease in females; statistically 
      differences were observed in the clinical features of age at diagnosis, 
      hypertension and peripheral neuropathy for the variant and wild genotype of the 
      rs3811463 in T2DM. In summary, the results indicated that the rs3811463 
      polymorphism in the let-7/Lin28 pathway could significantly increase the risk of 
      T2DM.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial 
      Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang 
      325035, China.
FAU - Zhang, Longyi
AU  - Zhang L
FAU - Fan, Runping
AU  - Fan R
FAU - Guo, Nengneng
AU  - Guo N
FAU - Xiong, Chunhui
AU  - Xiong C
FAU - Wang, Lin
AU  - Wang L
FAU - Jin, Sheng
AU  - Jin S
FAU - Li, Wei
AU  - Li W
FAU - Lu, Jianxin
AU  - Lu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130506
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Lin28A protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (mirnlet7 microRNA, human)
SB  - IM
MH  - Aged
MH  - Binding Sites/genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - MicroRNAs/*genetics
MH  - Middle Aged
MH  - Models, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - RNA-Binding Proteins/*genetics
MH  - Risk Factors
MH  - Sex Characteristics
MH  - Sex Distribution
EDAT- 2013/05/11 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/05/11 06:00
PHST- 2012/11/08 00:00 [received]
PHST- 2013/04/24 00:00 [revised]
PHST- 2013/04/26 00:00 [accepted]
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S0303-7207(13)00199-8 [pii]
AID - 10.1016/j.mce.2013.04.022 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2013 Aug 15;375(1-2):53-7. doi: 10.1016/j.mce.2013.04.022. 
      Epub 2013 May 6.