PMID- 23660308
OWN - NLM
STAT- MEDLINE
DCOM- 20131227
LR  - 20181202
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 109
DP  - 2013 Sep 1
TI  - Physicochemical and biological evaluation of poly(ethylene glycol) methacrylate 
      grafted onto poly(dimethyl siloxane) surfaces for prosthetic devices.
PG  - 228-35
LID - S0927-7765(13)00237-3 [pii]
LID - 10.1016/j.colsurfb.2013.03.050 [doi]
AB  - Poly(dimethyl siloxane) (PDMS) was surface-polymerized with poly(ethylene 
      glycol)methacrylate (PEGMA) by surface-initiated atom transfer radical 
      polymerization (SI-ATRP) in aqueous media at room temperature. Modification of 
      the PDMS surface followed a three-step procedure: (i) PDMS surface hydroxylation 
      by UV/ozone exposure, immediately followed by (ii) covalent attachment of the 
      initiator, 1-trichlorosilyl-2-(chloromethylphenyl)ethane, onto the hydroxylated 
      PDMS, via chemical vapor deposition; finally (iii) PDMS surface-polymerization of 
      PEGMA by ATRP. Modified PDMS was characterized by water contact angle 
      measurement, SEM, FTIR-ATR, and XPS. Results showed that modified surfaces had a 
      hydrophilic character, given the water contact angles around 60 degrees ; FTIR-ATR and 
      XPS analysis confirmed the presence of polymerized PEGMA on the surface of PDMS 
      and the adhesion of Staphylococcus aureus GB 2/1 and Streptococcus salivarius GB 
      24/9 onto the modified surfaces was inhibited 94% and 81%, respectively. Finally, 
      the modified PDMS showed no evidence of cytotoxic effects in in vitro assays 
      using human skin fibroblasts.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Goncalves, Sara
AU  - Goncalves S
AD  - IBB-Institute for Biotechnology and Bioengineering, Centre of Biological 
      Engineering, University of Minho, Braga, Portugal.
FAU - Leiros, Ana
AU  - Leiros A
FAU - van Kooten, Theo
AU  - van Kooten T
FAU - Dourado, Fernando
AU  - Dourado F
FAU - Rodrigues, Ligia R
AU  - Rodrigues LR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130409
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (poly(ethylene glycol) methacrylate polymer)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 63148-62-9 (baysilon)
SB  - IM
MH  - Anti-Bacterial Agents/*chemistry/*pharmacology
MH  - Chemistry, Physical
MH  - Dimethylpolysiloxanes/*chemistry/*pharmacology
MH  - Fibroblasts/cytology
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Polyethylene Glycols/*chemistry/*pharmacology
MH  - Polymerization
MH  - *Prostheses and Implants
MH  - Skin/cytology
MH  - Staphylococcus aureus/drug effects
MH  - Streptococcus/drug effects
MH  - Structure-Activity Relationship
MH  - Surface Properties
EDAT- 2013/05/11 06:00
MHDA- 2013/12/29 06:00
CRDT- 2013/05/11 06:00
PHST- 2012/10/24 00:00 [received]
PHST- 2013/03/21 00:00 [revised]
PHST- 2013/03/27 00:00 [accepted]
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/12/29 06:00 [medline]
AID - S0927-7765(13)00237-3 [pii]
AID - 10.1016/j.colsurfb.2013.03.050 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2013 Sep 1;109:228-35. doi: 
      10.1016/j.colsurfb.2013.03.050. Epub 2013 Apr 9.