PMID- 23660318
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20141120
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 93
IP  - 7
DP  - 2013 Feb 19
TI  - [Correlation of muscular impairment rating scale with myopathological changes in 
      myotonic dystrophy type 1].
PG  - 508-11
AB  - OBJECTIVE: To explore the relationship between muscular impairment rating scale 
      (MIRS) and myopathological changes of myotonic dystrophy type 1 (DM1). METHODS: A 
      total of 46 patients at our hospital from May 2003 to June 2011 were diagnosed as 
      DM1. There were 30 males and 16 females. The age of onset ranged from 10 to 57 
      years old. The major symptoms included distal extremity weakness and myotonia. 
      They were assessed with MIRS and muscle biopsies. The relationship was examined 
      between MIRS and the variation of fiber size, central nuclear, ragged red fibers, 
      proliferation of connective tissue, sarcoplasmic mass. Statistic analysis of 
      pathological changes was made between the groups of MIRS >/= 4 and </= 3. RESULTS: 
      The scores of MIRS were 2 (n = 8), 3 (n = 14), 4 (n = 23) and 5 (n = 1). MIRS had 
      significant correlations with variations of fiber size (P = 0.039, r = 0.305), 
      degree of nuclear translocation (P = 0.002, r = 0.451) and ragged red fibers (P = 
      0.013, r = 0.364). But there was no significant correlation with the 
      proliferation of connective tissue and sarcoplasmic mass. There were significant 
      differences in nuclear translocation and ragged red fibers. But no significant 
      difference existed in variations of fiber size between the groups of MIRS >/= 4 and 
      </= 3. CONCLUSION: The rating scale of MIRS has a certain myopathological basis, 
      especially with regards to the changes in nuclear translocation and ragged red 
      fibers.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Neurology, Peking University First Hospital, Beijing 100034, China.
FAU - Liu, Qi
AU  - Liu Q
FAU - Wang, Zhao-xia
AU  - Wang ZX
FAU - Zhang, Wei
AU  - Zhang W
FAU - Yuan, Yun
AU  - Yuan Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*pathology
MH  - Myotonic Dystrophy/*pathology
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2013/05/11 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2013 Feb 19;93(7):508-11.