PMID- 23660362
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 23
IP  - 9
DP  - 2013 May 6
TI  - Mucosal immunology of food allergy.
PG  - R389-400
LID - S0960-9822(13)00214-5 [pii]
LID - 10.1016/j.cub.2013.02.043 [doi]
AB  - Food allergies are increasing in prevalence at a higher rate than can be 
      explained by genetic factors, suggesting a role for as yet unidentified 
      environmental factors. In this review, we summarize the state of knowledge about 
      the healthy immune response to antigens in the diet and the basis of immune 
      deviation that results in immunoglobulin E (IgE) sensitization and allergic 
      reactivity to foods. The intestinal epithelium forms the interface between the 
      external environment and the mucosal immune system, and emerging data suggest 
      that the interaction between intestinal epithelial cells and mucosal dendritic 
      cells is of particular importance in determining the outcome of immune responses 
      to dietary antigens. Exposure to food allergens through non-oral routes, in 
      particular through the skin, is increasingly recognized as a potentially 
      important factor in the increasing rate of food allergy. There are many open 
      questions on the role of environmental factors, such as dietary factors and 
      microbiota, in the development of food allergy, but data suggest that both have 
      an important modulatory effect on the mucosal immune system. Finally, we discuss 
      recent developments in our understanding of immune mechanisms of clinical 
      manifestations of food allergy. New experimental tools, particularly in the field 
      of genomics and the microbiome, are likely to shed light on factors responsible 
      for the growing clinical problem of food allergy.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Berin, M Cecilia
AU  - Berin MC
AD  - Pediatric Allergy and Immunology, Box 1198, One Gustave L. Levy Place, New York, 
      NY 10029, USA. cecilia.berin@mssm.edu
FAU - Sampson, Hugh A
AU  - Sampson HA
LA  - eng
GR  - R01 AI093577/AI/NIAID NIH HHS/United States
GR  - U19 AI066738/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Allergens)
RN  - 0 (Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*analysis
MH  - Antigens/blood
MH  - Dendritic Cells/immunology
MH  - Diet
MH  - *Environmental Exposure
MH  - Food/*adverse effects
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - *Immunity, Mucosal
MH  - Immunoglobulin E/immunology
MH  - Intestinal Mucosa/*immunology
MH  - Microbiota
PMC - PMC3667506
MID - NIHMS474462
EDAT- 2013/05/11 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/05/06
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/05/06 00:00 [pmc-release]
AID - S0960-9822(13)00214-5 [pii]
AID - 10.1016/j.cub.2013.02.043 [doi]
PST - ppublish
SO  - Curr Biol. 2013 May 6;23(9):R389-400. doi: 10.1016/j.cub.2013.02.043.