PMID- 23661457
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20130510
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 12
IP  - 2
DP  - 2013 Apr 25
TI  - Evaluation of a histocompatibility antigen related to hepatitis B virus in 
      patients with hepatocellular carcinoma in the western Brazilian Amazon.
PG  - 1336-46
LID - 10.4238/2013.April.25.5 [doi]
AB  - Hepatocellular carcinoma is an infection of variable incidence that can be caused 
      by hepatitis B virus (HBV), which is endemic in the Amazon region. The diagnosis 
      of HBV can be performed through the use of serum markers such as the hepatitis B 
      surface antigen. The chronic HBV can cause mutagenesis and carcinogenesis, being 
      the susceptibility of infection due to allele human leukocyte antigen (HLA). 
      Thus, we evaluated the clinical, molecular and laboratory profile 
      (histocompatibility complex) of HBV in 22 patients with hepatocellular carcinoma 
      in Amazonia, including 18 males and 4 females, using a blood sample for generic 
      HLA class II. The results showed increased frequency of disease evolution in 
      adults between 25 and 64 years old, who comprised 19 of the 22 patients studied. 
      Most patients (16/22) presented high levels of alpha-fetoprotein and 
      transaminases (14/22). The most common HLA alleles were DRB1 04 (8/44), DRB1 08 
      (9/44), DRB 03 (16/44), and DQB1 04 (9/44). When we compared specific phenotype 
      frequencies of HLA-DRB1 between patients and controls, we found that patients had 
      a significantly higher frequency of allele DRB1 08 and a significantly lower 
      frequency of DRB1 07 and DRB1 12 compared to previous studies on Asian and 
      Amazonian populations suggesting ethnic differences. We suggest that alleles 
      HLA-DRB 08, HLA-DRB 03 and HLA-DQB1 04 may be risk factors for hepatocellular 
      carcinoma in Amazon.
FAU - Chalub, S R S
AU  - Chalub SR
AD  - Departamento de Cirurgia Digestiva, Universidade Federal do Amazonas, Manaus, AM, 
      Brasil. sidney.chalub@hotmail.com
FAU - da Silva, R M
AU  - da Silva RM
FAU - da Silva, A P S
AU  - da Silva AP
FAU - de Aquino, P F
AU  - de Aquino PF
FAU - Sadahiro, A
AU  - Sadahiro A
FAU - Kalil, A N
AU  - Kalil AN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130425
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Brazil
MH  - Carcinoma, Hepatocellular/*genetics/immunology
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Hepatitis B virus/immunology
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Liver Neoplasms/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Sex Factors
MH  - Young Adult
EDAT- 2013/05/11 06:00
MHDA- 2013/10/23 06:00
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - gmr2250 [pii]
AID - 10.4238/2013.April.25.5 [doi]
PST - epublish
SO  - Genet Mol Res. 2013 Apr 25;12(2):1336-46. doi: 10.4238/2013.April.25.5.