PMID- 23662116
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130513
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Discovery of endothelium and mesenchymal properties of primo vessels in the 
      mesentery.
PG  - 205951
LID - 10.1155/2013/205951 [doi]
LID - 205951
AB  - Recent evidences demonstrated that endothelial-to-mesenchymal transition (EndMT) 
      has a crucial role in cancer and is recognized as a unique source of 
      cancer-associated fibroblasts (CAFs). Primo vascular system (PVS) is a new 
      circulatory system which may play an important role in cancer metastasis and 
      regeneration. In the current study, we applied previously established time-saving 
      method to identify primo vessels and further investigated the immunocytochemical 
      properties of primo vessels. Both primo vessels and primary primo vessel cells in 
      the mesentery expressed endothelial markers and fibroblast markers. 
      Double-labeling experiments demonstrated that endothelial and fibroblast markers 
      are coexpressed in primo vessels. In addition, under the stimulation of TGF-beta1 in 
      vitro, primary primo vessel cells differentiated into fibroblasts. Therefore, we 
      found that primo vessels in the mesentery had a transitional structure between 
      endothelium and mesenchymal. This is a new finding of EndMT in normal postnatal 
      animals.
FAU - Ping, An
AU  - Ping A
AD  - Renmin Hospital of Wuhan University, Wuhan 430-060, China.
FAU - Zhendong, Su
AU  - Zhendong S
FAU - Jingxing, Dai
AU  - Jingxing D
FAU - Yaling, Liu
AU  - Yaling L
FAU - Bae, Kyung-Hee
AU  - Bae KH
FAU - Shiyun, Tan
AU  - Shiyun T
FAU - Hesheng, Luo
AU  - Hesheng L
FAU - Soh, Kwang-Sup
AU  - Soh KS
FAU - Ryu, Yeon Hee
AU  - Ryu YH
FAU - Kim, Sungchul
AU  - Kim S
LA  - eng
PT  - Journal Article
DEP - 20130415
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3639629
EDAT- 2013/05/11 06:00
MHDA- 2013/05/11 06:01
PMCR- 2013/04/15
CRDT- 2013/05/11 06:00
PHST- 2012/11/27 00:00 [received]
PHST- 2013/01/22 00:00 [revised]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/05/11 06:01 [medline]
PHST- 2013/04/15 00:00 [pmc-release]
AID - 10.1155/2013/205951 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:205951. doi: 10.1155/2013/205951. 
      Epub 2013 Apr 15.