PMID- 23662939
OWN - NLM
STAT- MEDLINE
DCOM- 20140729
LR  - 20131205
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 80
IP  - 1
DP  - 2014 Jan
TI  - Relation of insulin-like growth factor-I and IGF binding protein 3 with markers 
      of inflammation: results of a population-based study.
PG  - 148-54
LID - 10.1111/cen.12241 [doi]
AB  - OBJECTIVE: Previous studies in acromegaly and growth hormone deficiency observed 
      inverse associations between insulin-like growth factor-I (IGF-I) levels and 
      inflammatory biomarkers including high-sensitive C-reactive protein (hsCRP), 
      interleukin-6 or fibrinogen. We aimed to assess the relations between IGF-I or 
      IGF binding protein 3 (IGFBP-3) levels and hsCRP, interleukin-6, fibrinogen and 
      white blood cell count (WBC) in a population-based sample. DESIGN AND PATIENTS: 
      Data from 3480 subjects from the population-based Study of Health in Pomerania 
      (SHIP) were used. IGF-I, IGFBP-3 and inflammatory biomarkers were measured. 
      Analysis of variance (anova), quantile regression models and logistic regression 
      models, adjusted for age, smoking, diabetes mellitus and waist circumference, 
      were performed. MEASUREMENTS AND RESULTS: anova and/or quantile regression showed 
      inverse associations between IGF-I and hsCRP as well as positive associations 
      between IGF-I and fibrinogen among both sexes. Furthermore, the odds of elevated 
      fibrinogen levels increased with increasing IGF-I levels (per SD IGF-I increase: 
      men: odds ratio (OR) 1.35 [95% confidence interval (CI) 1.04, 1.55]; women: OR 
      1.44 [95% CI 1.21, 1.71]) in both sexes, whereas the odds of increased hsCRP 
      (women: OR 0.46 [95% CI 0.36, 0.58]) and interleukin-6 (men: odds ratio (OR) 0.77 
      [95% CI 0.61, 0.96]; women: OR 0.69 [95% CI 0.55, 0.86]) decreased. CONCLUSION: 
      Serum IGF-I levels are associated with inflammatory biomarkers including hsCRP, 
      interleukin-6 and fibrinogen. Further experimental studies are needed to 
      elucidate the mechanisms underlying the relation between the GH/IGF axis and the 
      inflammatory system.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Lohr, Johannes
AU  - Lohr J
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Greifswald, Germany.
FAU - Grotevendt, Anne
AU  - Grotevendt A
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Volzke, Henry
AU  - Volzke H
FAU - Wallaschofski, Henri
AU  - Wallaschofski H
FAU - Friedrich, Nele
AU  - Friedrich N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130606
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Interleukin-6)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - Fibrinogen
MH  - Humans
MH  - Inflammation/*blood/*metabolism
MH  - Insulin-Like Growth Factor Binding Protein 3/*metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
EDAT- 2013/05/15 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/02/26 00:00 [received]
PHST- 2013/04/25 00:00 [revised]
PHST- 2013/04/26 00:00 [revised]
PHST- 2013/05/06 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - 10.1111/cen.12241 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2014 Jan;80(1):148-54. doi: 10.1111/cen.12241. Epub 2013 
      Jun 6.