PMID- 23664268
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 150
IP  - 2
DP  - 2013 Sep 5
TI  - Serum levels of brain-derived neurotrophic factor are unchanged after 
      transcranial direct current stimulation in treatment-resistant depression.
PG  - 659-63
LID - S0165-0327(13)00240-1 [pii]
LID - 10.1016/j.jad.2013.03.015 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays an important role in 
      differentiation and repair of neurons in the adult brain. BDNF serum levels have 
      been found to be lower in depressed patients than in healthy subjects. In a 
      couple of studies, effective antidepressant treatment including electroconvulsive 
      therapy led to an increase in BDNF serum levels. As transcranial direct current 
      stimulation (tDCS) is currently discussed as novel therapeutic intervention in 
      major depression, we investigated BDNF serum levels during tDCS in 
      therapy-resistant depression. METHODS: Twenty-two patients with a major 
      depressive episode participated in a double-blind placebo-controlled trial and 
      received randomized cross over treatment with 2 weeks active and 2 weeks sham 
      tDCS (1 or 2 mA for 20 min, anode over the left dorsolateral prefrontal cortex, 
      cathode right supraorbital cortex). RESULTS: Clinical assessment only showed a 
      modest and non-significant improvement in HAMD, BDI and CGI in both groups. BDNF 
      serum levels were measured at baseline, after 2 and after 4 weeks. There was 
      neither a significant change of BDNF levels following active tDCS, nor were 
      severity of depressive symptoms and BDNF levels correlated. LIMITATIONS: The 
      small sample size, its heterogeneity, the short observation period and a 
      cross-over design without an interval between both conditions. CONCLUSIONS: tDCS 
      did not change BDNF serum levels unlike other established antidepressant 
      interventions in this treatment resistant sample. However, larger studies are 
      needed.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Palm, Ulrich
AU  - Palm U
AD  - Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, 
      Munich, Germany. ulrich.palm@med.uni-muenchen.de
FAU - Fintescu, Zoe
AU  - Fintescu Z
FAU - Obermeier, Michael
AU  - Obermeier M
FAU - Schiller, Christina
AU  - Schiller C
FAU - Reisinger, Eva
AU  - Reisinger E
FAU - Keeser, Daniel
AU  - Keeser D
FAU - Pogarell, Oliver
AU  - Pogarell O
FAU - Bondy, Brigitta
AU  - Bondy B
FAU - Zill, Peter
AU  - Zill P
FAU - Padberg, Frank
AU  - Padberg F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130507
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cerebral Cortex
MH  - Cross-Over Studies
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - Depressive Disorder, Treatment-Resistant/*blood/*therapy
MH  - Double-Blind Method
MH  - Electric Stimulation Therapy/*methods
MH  - Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/physiology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - BDNF serum levels
OT  - Major depressive disorder
OT  - Transcranial direct current stimulation
OT  - tDCS
EDAT- 2013/05/15 06:00
MHDA- 2014/05/06 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/02/14 00:00 [received]
PHST- 2013/03/13 00:00 [revised]
PHST- 2013/03/14 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
AID - S0165-0327(13)00240-1 [pii]
AID - 10.1016/j.jad.2013.03.015 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Sep 5;150(2):659-63. doi: 10.1016/j.jad.2013.03.015. Epub 
      2013 May 7.