PMID- 23664439
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20161125
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 168
IP  - 4
DP  - 2013 Oct 9
TI  - Association between levels of serum perfluorooctane sulfate and carotid artery 
      intima-media thickness in adolescents and young adults.
PG  - 3309-16
LID - S0167-5273(13)00626-8 [pii]
LID - 10.1016/j.ijcard.2013.04.042 [doi]
AB  - BACKGROUND: Perfluorinated chemicals (PFCs) have been widely used for years in a 
      variety of products worldwide. Although epidemiological findings have shown that 
      PFC levels are positively associated with cholesterol and uric acid levels, it is 
      unknown whether PFCs are associated with atherosclerosis. METHODS: We recruited 
      664 subjects (12-30 years) from a population-based sample of adolescents and 
      young adults based on a mass urine screening to determine the relationship 
      between serum levels of PFCs and carotid intima-media thickness (CIMT). RESULTS: 
      The median concentrations and ranges of perfluorooctanoic acid (PFOA), 
      perfluorooctane sulfate (PFOS), perfluorononanoic acid (PFNA), and 
      perfluorodecanoic acid (PFUA) were 3.49 (0.75-52.2) ng/mL, 8.65 (0.11-85.90) 
      ng/mL, 0.38 (0.38-25.4) ng/mL, and 6.59 (1.50-105.7) ng/mL, respectively. After 
      controlling for age, gender, smoking status, systolic blood pressure, body mass 
      index, low-density lipoprotein cholesterol, triglyceride, high-sensitivity 
      C-reactive protein, and homeostasis model assessment of insulin resistance, 
      multiple linear regression analysis revealed that CIMT increased significantly 
      across quartiles of PFOS (0.434 mm, 0.446 mm, 0.458 mm, 0.451 mm; P for trend 
      <0.001). Subpopulation analysis showed the association between PFOS and CIMT was 
      more evident and significant in females, non-smokers, subjects of age 12-19 
      years, BMI<24, and those with APOE genotype of E2 carrier and E3/E3. CONCLUSIONS: 
      Higher serum concentrations of PFOS were associated with an increase of carotid 
      IMT in this cohort of adolescents and young adults. Further studies are warranted 
      to clarify the causal relationship between PFOS and atherosclerosis.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Lin, Chien-Yu
AU  - Lin CY
AD  - Department of Internal Medicine, En Chu Kong Hospital, Taipei County, Taiwan; 
      School of Medicine, Fu Jen Catholic University, Taipei County, Taiwan.
FAU - Lin, Lian-Yu
AU  - Lin LY
FAU - Wen, Ting-Wen
AU  - Wen TW
FAU - Lien, Guang-Wen
AU  - Lien GW
FAU - Chien, Kuo-Liong
AU  - Chien KL
FAU - Hsu, Sandy H J
AU  - Hsu SH
FAU - Liao, Chien-Chang
AU  - Liao CC
FAU - Sung, Fung-Chang
AU  - Sung FC
FAU - Chen, Pau-Chung
AU  - Chen PC
FAU - Su, Ta-Chen
AU  - Su TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130507
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Fluorocarbons)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alkanesulfonic Acids/*blood
MH  - Biomarkers/blood
MH  - *Carotid Intima-Media Thickness
MH  - Child
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorocarbons/*blood
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Young Adult
OTO - NOTNLM
OT  - Carotid intima-media thickness
OT  - Perfluorinated chemicals
OT  - Perfluorononanoic acid
OT  - Perfluorooctane sulfate
EDAT- 2013/05/15 06:00
MHDA- 2014/06/27 06:00
CRDT- 2013/05/14 06:00
PHST- 2012/05/05 00:00 [received]
PHST- 2013/03/28 00:00 [revised]
PHST- 2013/04/06 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - S0167-5273(13)00626-8 [pii]
AID - 10.1016/j.ijcard.2013.04.042 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Oct 9;168(4):3309-16. doi: 10.1016/j.ijcard.2013.04.042. Epub 
      2013 May 7.