PMID- 23664446
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20190221
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 81
IP  - 2
DP  - 2013 Aug
TI  - EML4-ALK translocation in both metachronous second primary lung sarcomatoid 
      carcinoma and lung adenocarcinoma: a case report.
PG  - 297-301
LID - S0169-5002(13)00121-9 [pii]
LID - 10.1016/j.lungcan.2013.03.016 [doi]
AB  - The EML4-ALK gene translocation was described in a non small cell lung cancer 
      (NSCLC) subset, with a potent oncogenic activity. It represents one of the newest 
      molecular targets in NSCLC. We report on the case of a metachronous second 
      primary lung sarcomatoid carcinoma after resection of lung adenocarcinoma both 
      with ALK translocation, in a non-smoking patient. EML4-ALK rearrangement was 
      detected with immunohistochemistry and confirmed with fluorescent in situ 
      hybridization (FISH). To assess the clonal relationship between the two tumors, 
      both adenocarcinoma and sarcomatoid carcinoma were analyzed by array comparative 
      genomic hybridization (aCGH). We observed different genomic profiles suggesting 
      that the tumors arose independently and were thus multiple primaries. To the best 
      of our knowledge, this is the first report concerning the presence of the 
      EML4-ALK fusion gene in a sarcomatoid carcinoma of the lung. Crizotinib, the ALK 
      tyrosine kinase inhibitor, is highly effective in ALK-rearranged NSCLC; 
      therefore, it may be imperative to identify all NSCLC that harbor ALK 
      translocations in the near future. Starting from our evidence, tumors with 
      sarcomatoid histology may need to be screened for the presence of EML4-ALK 
      rearrangement.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Ali, Greta
AU  - Ali G
AD  - Unit of Pathological Anatomy, Azienda Ospedaliera Universitaria Pisana, Pisa, 
      Italy.
FAU - Proietti, Agnese
AU  - Proietti A
FAU - Niccoli, Cristina
AU  - Niccoli C
FAU - Pelliccioni, Serena
AU  - Pelliccioni S
FAU - Borrelli, Nicla
AU  - Borrelli N
FAU - Giannini, Riccardo
AU  - Giannini R
FAU - Lupi, Cristiana
AU  - Lupi C
FAU - Valetto, Angelo
AU  - Valetto A
FAU - Bertini, Veronica
AU  - Bertini V
FAU - Lucchi, Marco
AU  - Lucchi M
FAU - Mussi, Alfredo
AU  - Mussi A
FAU - Fontanini, Gabriella
AU  - Fontanini G
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130510
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (EML4-ALK fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Adenocarcinoma/*genetics
MH  - Adenocarcinoma of Lung
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*genetics
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Sarcoma/*genetics
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - Adenocarcinoma
OT  - Array comparative genomic hybridization
OT  - EML4-ALK rearrangement
OT  - Fluorescent in situ hybridization
OT  - Immunohistochemistry
OT  - Lung
OT  - Reverse transcriptase-polymerase chain reaction
OT  - Sarcomatoid carcinoma
EDAT- 2013/05/15 06:00
MHDA- 2014/05/03 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/01/04 00:00 [received]
PHST- 2013/03/14 00:00 [revised]
PHST- 2013/03/16 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - S0169-5002(13)00121-9 [pii]
AID - 10.1016/j.lungcan.2013.03.016 [doi]
PST - ppublish
SO  - Lung Cancer. 2013 Aug;81(2):297-301. doi: 10.1016/j.lungcan.2013.03.016. Epub 
      2013 May 10.