PMID- 23664605
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20161125
IS  - 2589-0646 (Electronic)
IS  - 2589-0646 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Mar
TI  - A rare case with typical acute promyelocytic leukemia morphology associated with 
      isolated isochromosome 17q without RARalpha rearrangement.
PG  - 42-5
LID - S1658-3876(13)00006-X [pii]
LID - 10.1016/j.hemonc.2013.02.004 [doi]
AB  - Isolated isochromosome 17q has rarely been reported in hematologic tumor 
      patients. A 37-year-old man was admitted with fever and weakness. Blood routine 
      test showed anemia and thrombocytopenia. The morphology and immunology of bone 
      marrow cells conform to classic acute promyelocytic leukemia (APL). But the 
      karyotype showed isolated isochromosome 17q without t(15;17) (q22;q12). Rverse 
      transcriptase polymerase chain reaction (RT-PCR) for PML -RARa was negative and 
      fluorescence in situ hybridization (FISH) analysis showed no RARa gene 
      rearrangements.The patient responded poorly to all trans retinoic acid and 
      traditional chemotherapy with daunorubicin and cytarabine and survived only 43 
      days after diagnosis. The pathogenesis and the best treatment choice for this 
      kind of patients are not clear currently.
CI  - Copyright (c) 2013 King Faisal Specialist Hospital & Research Centre. Published by 
      Elsevier B.V. All rights reserved.
FAU - Duan, Yanchao
AU  - Duan Y
AD  - Affiliated Hospital of Taishan Medical University, Taian, Shandong, China. 
      duansuper@yahoo.cn
FAU - Nie, Jing
AU  - Nie J
FAU - Zhang, Zhirong
AU  - Zhang Z
FAU - Zhou, Li
AU  - Zhou L
FAU - Zhu, Feng
AU  - Zhu F
FAU - Zhang, Hong
AU  - Zhang H
FAU - Zhu, Hongbo
AU  - Zhu H
FAU - Shang, Wenqing
AU  - Shang W
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130305
PL  - Saudi Arabia
TA  - Hematol Oncol Stem Cell Ther
JT  - Hematology/oncology and stem cell therapy
JID - 101468532
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 04079A1RDZ (Cytarabine)
RN  - ZS7284E0ZP (Daunorubicin)
SB  - IM
MH  - Antibiotics, Antineoplastic/therapeutic use
MH  - Bone Marrow/pathology
MH  - *Chromosomes, Human, Pair 17
MH  - Cytarabine/therapeutic use
MH  - Daunorubicin/therapeutic use
MH  - Drug Therapy, Combination
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Isochromosomes
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*diagnosis/drug therapy
MH  - Male
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoic Acid Receptor alpha
EDAT- 2013/05/15 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - S1658-3876(13)00006-X [pii]
AID - 10.1016/j.hemonc.2013.02.004 [doi]
PST - ppublish
SO  - Hematol Oncol Stem Cell Ther. 2013 Mar;6(1):42-5. doi: 
      10.1016/j.hemonc.2013.02.004. Epub 2013 Mar 5.