PMID- 23664829
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20130614
IS  - 0210-5705 (Print)
IS  - 0210-5705 (Linking)
VI  - 36
IP  - 6
DP  - 2013 Jun-Jul
TI  - [Immunophenotypic classification of 3 cases of hepatocellular adenoma. 
      Differential diagnosis with focal nodular hyperplasia].
PG  - 388-95
LID - S0210-5705(13)00122-2 [pii]
LID - 10.1016/j.gastrohep.2013.02.013 [doi]
AB  - Interest in adenomas has been renewed by the discovery of the molecular changes 
      in these tumors. The latest World Health Organization publication on 
      gastrointestinal tract tumors (2010) includes four types of hepatic adenomas, 
      which are well characterized immunohistochemically, genotypically and 
      phenotypically. In these tumors, medical history and morphological behavior play 
      an important role in determining the risk of malignancy, mainly in adenomas with 
      a b-catenin mutation. The presence of steatosis, inflammation, vascular changes 
      linked to response to L-FABP, serum amyloid A, and glutamyl synthetase help to 
      classify these tumors into four groups: hepatocellular adenomas with the HNF1A 
      mutation (H-HCA), those with the b-catenin mutation (b-HCA), inflammatory HCA 
      (IHCA), and HCA without markers. The absence of glypican 3 expression, HSP 70 and 
      perivenular mapping of glutamyl synthetase helps to distinguish these tumors from 
      well differentiated hepatocellular carcinoma. We describe the clinical, 
      morphological and immunophenotypic features of three patients diagnosed with 
      hepatic adenomas in a 2-year period.
CI  - Copyright (c) 2012 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.
FAU - Perez Rojas, Judith
AU  - Perez Rojas J
AD  - Servicio de Anatomia Patologica, Hospital Universitario La Fe, Valencia, Espana. 
      judithpr@terra.es
FAU - Guarin Corredor, Maria Juliana
AU  - Guarin Corredor MJ
FAU - Artes Martinez, Maria Josefa
AU  - Artes Martinez MJ
FAU - Vera Sempere, Francisco Jose
AU  - Vera Sempere FJ
FAU - Brisa Estelles, Carmen
AU  - Brisa Estelles C
FAU - Huart Peris, Maria Carmen
AU  - Huart Peris MC
FAU - Hernandez Giron, Soraya
AU  - Hernandez Giron S
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Clasificacion inmunofenotipica de 3 casos de adenomas hepatocelulares. 
      Diagnostico diferencial con hiperplasia nodular focal.
DEP - 20130510
PL  - Spain
TA  - Gastroenterol Hepatol
JT  - Gastroenterologia y hepatologia
JID - 8406671
SB  - IM
MH  - Adenoma, Liver Cell/*classification/*diagnosis/immunology
MH  - Adult
MH  - Diagnosis, Differential
MH  - Female
MH  - Focal Nodular Hyperplasia/*diagnosis
MH  - Humans
MH  - Immunophenotyping
MH  - Liver Neoplasms/*classification/*diagnosis/immunology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2013/05/15 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/05/14 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/01/14 00:00 [revised]
PHST- 2013/02/05 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - S0210-5705(13)00122-2 [pii]
AID - 10.1016/j.gastrohep.2013.02.013 [doi]
PST - ppublish
SO  - Gastroenterol Hepatol. 2013 Jun-Jul;36(6):388-95. doi: 
      10.1016/j.gastrohep.2013.02.013. Epub 2013 May 10.