PMID- 23666488
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20211021
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 80
IP  - 12
DP  - 2013 Dec
TI  - Do serum C-reactive protein and interleukin-6 predict kidney scarring after 
      urinary tract infection?
PG  - 1002-6
LID - 10.1007/s12098-013-1045-4 [doi]
AB  - OBJECTIVE: To investigate if serum C-reactive protein (s-CRP) and interleukin 6 
      (s-IL6) provide information for predicting renal damage and for DMSA patient 
      selection in children with urinary tract infection (UTI). METHODS: This 
      observational study was carried out in children with UTI. s-CRP and s-IL6 were 
      measured at UTI diagnosis. Patients forming renal scarring were identified by 
      DMSA scans. The usefulness of s-CRP and s-IL6 measurements for nephropathy 
      scarring diagnosis was evaluated using diagnostic quality and efficiency indexes. 
      RESULTS: Thirty-two children were included in the study. Eight showed renal 
      scarring after the follow-up. The s-CRP was 110.23 +/- 59.69 mg/L and 52.46 +/- 63.13 
      mg/L for patients with and without renal scarring. The s-IL6 concentration was 
      18.34 +/- 11.80 pg/mL and 8.07 +/- 9.51 pg/mL respectively. The cut-off points for 
      optimum nephropathy scarring diagnosis were 115 mg/L for s-CRP and 20 pg/mL for 
      s-IL6. The value of highest sensitivity for s-CRP was >5 mg/L (S:100 %) and 
      greatest specificity was >150 mg/L (Sp:95.83). The highest sensitivity for s-IL6 
      was >4 pg/mL (S:100 %) and the maximum specificity was >40 pg/mL (Sp:100 %). 
      CONCLUSIONS: Results confirm that children who will develop renal scarring show 
      higher levels of s-IL6 and s-CRP at UTI diagnosis. However, none of the 
      techniques provide sufficient information for predicting renal damage in all 
      patients and for DMSA patient selection.
FAU - Rodriguez, Luis Miguel
AU  - Rodriguez LM
AD  - Department of Pediatric Nephrology, Complejo Asistencial Universitario (CAULE), 
      Leon, Spain, luism@arrakis.es.
FAU - Robles, Belen
AU  - Robles B
FAU - Marugan, Jose Manuel
AU  - Marugan JM
FAU - Suarez, Angeles
AU  - Suarez A
FAU - Garcia Ruiz de Morales, Jose Maria
AU  - Garcia Ruiz de Morales JM
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130511
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
RN  - 0 (Interleukin-6)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Cicatrix/pathology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interleukin-6/*blood
MH  - Kidney/*pathology
MH  - Male
MH  - Sensitivity and Specificity
MH  - Urinary Tract Infections/*pathology
EDAT- 2013/05/15 06:00
MHDA- 2015/01/21 06:00
CRDT- 2013/05/14 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2013/04/10 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - 10.1007/s12098-013-1045-4 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2013 Dec;80(12):1002-6. doi: 10.1007/s12098-013-1045-4. Epub 
      2013 May 11.