PMID- 23666497
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20211021
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 36
IP  - 6
DP  - 2013 Dec
TI  - Expression of pro-inflammatory cytokines and the risk of intracranial aneurysm.
PG  - 1195-200
LID - 10.1007/s10753-013-9655-6 [doi]
AB  - Intracranial aneurysm (IA) lingers as a potentially devastating clinical problem, 
      in which inflammation acts as a critical contributor to the pathogenesis of this 
      disease. Cytokines play a major role in regulating inflammation. The aim of this 
      study was to gain insight in the inflammatory response in IA by assessing plasma 
      cytokine profiles. Plasma levels of 10 cytokines were quantified by multiplex 
      protein arrays in 66 patients with IA and 78 healthy controls. Results showed 
      that plasma level of interleukin 1 beta (IL-1beta) was 2.4-fold higher in patients 
      than in controls (p < 0.05). The level of monocyte chemoattractant protein-1 
      (MCP-1) was 2.8-fold higher in patient than in controls (p < 0.01). The level of 
      tumor necrosis factor-alpha (TNF-alpha) was 2.1-fold higher in cases than in controls 
      (p < 0.001). When comparing the expression of cytokines in IA patients with 
      different characteristics, cases with ruptured aneurysm revealed increased level 
      of MCP-1 than those with unruptured aneurysm (p < 0.05), whereas cases with 
      multiple numbers of aneurysms demonstrated higher levels of MCP-1 and TNF-alpha than 
      those with single aneurysm (p < 0.05 and p < 0.05, respectively). These data 
      indicated that IL-1beta, MCP-1, and TNF-alpha were associated with increased risk of IA 
      and may affect the development of this disease.
FAU - Zhang, Hai-Feng
AU  - Zhang HF
AD  - Department of Neurosurgery, The General Hospital of Shenyang Military Region, 83 
      Wenhua Road, Shenyang, 110840, China.
FAU - Zhao, Ming-Guang
AU  - Zhao MG
FAU - Liang, Guo-Biao
AU  - Liang GB
FAU - Song, Zhen-Quan
AU  - Song ZQ
FAU - Li, Zhi-Qing
AU  - Li ZQ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-1beta/*blood
MH  - Intracranial Aneurysm/*diagnosis/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Risk
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2013/05/15 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1007/s10753-013-9655-6 [doi]
PST - ppublish
SO  - Inflammation. 2013 Dec;36(6):1195-200. doi: 10.1007/s10753-013-9655-6.