PMID- 23666691
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20130513
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 999
DP  - 2013
TI  - Detection of recurrent cytogenetic abnormalities in acute lymphoblastic and 
      myeloid leukemias using fluorescence in situ hybridization.
PG  - 79-91
LID - 10.1007/978-1-62703-357-2_5 [doi]
AB  - Cytogenetic identification of clonal abnormalities present in leukemia is 
      critical for accurate diagnosis of the disease and determination of specific 
      therapeutic interventions for the patient. Fluorescence in situ hybridization 
      (FISH) studies complement the diagnostic karyotype by providing a higher 
      resolution of analysis with clarification of rearrangements observed by G-banding 
      and identification of cryptic abnormalities not observed by the light microscope. 
      This chapter will discuss FISH methodology as practiced in the cancer cytogenetic 
      laboratory.
FAU - Vance, Gail H
AU  - Vance GH
AD  - Department of Medical and Molecular Genetics, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/genetics/*pathology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics/*pathology
MH  - Translocation, Genetic
EDAT- 2013/05/15 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/05/14 06:00
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - 10.1007/978-1-62703-357-2_5 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2013;999:79-91. doi: 10.1007/978-1-62703-357-2_5.