PMID- 23666698 OWN - NLM STAT- MEDLINE DCOM- 20131231 LR - 20130513 IS - 1940-6029 (Electronic) IS - 1064-3745 (Linking) VI - 999 DP - 2013 TI - Detection of genetic translocations in lymphoma using fluorescence in situ hybridization. PG - 189-202 LID - 10.1007/978-1-62703-357-2_12 [doi] AB - Certain lymphoma types are characterized by recurring genetic translocations. Detection of these translocations enables confirmation of a suspected diagnosis and provides a genetic marker which can be subsequently monitored and followed. Rapid and reliable identification of these molecular rearrangements is a key component in the workup of lymphoma. While conventional cytogenetics may be a useful tool in this regard, fluorescence in situ hybridization (FISH) offers additional advantages including the ability to use formalin-fixed tissues, no requirement for dividing cells, ability to score many cells, improved sensitivity, and faster turnaround time for results. FAU - Reichard, Kaaren K AU - Reichard KK AD - Department of Laboratory Medicine and Pathology, Division of Hematopathology, Mayo Clinic Rochester, Rochester, MN, USA. FAU - Robinett, Sheldon AU - Robinett S LA - eng PT - Journal Article PL - United States TA - Methods Mol Biol JT - Methods in molecular biology (Clifton, N.J.) JID - 9214969 SB - IM MH - Cytogenetics MH - Humans MH - In Situ Hybridization, Fluorescence/*methods MH - Lymphoma/*diagnosis/genetics/pathology MH - Translocation, Genetic/*genetics EDAT- 2013/05/15 06:00 MHDA- 2014/01/01 06:00 CRDT- 2013/05/14 06:00 PHST- 2013/05/14 06:00 [entrez] PHST- 2013/05/15 06:00 [pubmed] PHST- 2014/01/01 06:00 [medline] AID - 10.1007/978-1-62703-357-2_12 [doi] PST - ppublish SO - Methods Mol Biol. 2013;999:189-202. doi: 10.1007/978-1-62703-357-2_12.