PMID- 23667484
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 5
DP  - 2013
TI  - Exposure levels of environmental endocrine disruptors in mother-newborn pairs in 
      China and their placental transfer characteristics.
PG  - e62526
LID - 10.1371/journal.pone.0062526 [doi]
LID - e62526
AB  - There is a growing concern about the potential health effects of exposure to 
      various environmental chemicals during pregnancy and infancy. The placenta is 
      expected to be an effective barrier protecting the developing embryo against some 
      endocrine disruptors (EDs) circulating in maternal blood. The current study was 
      designed to assess in utero exposure levels of non-persistent organic pollutants 
      (non-POPs) and persistent organic pollutants (POPs) in Chinese newborns and 
      potential role of placenta barrier against fetal exposure to these commonly-used 
      environmental endocrine disruptors. A total of 230 newborn-mother pairs were 
      enrolled during 2010-2011, 201 pairs of which were recruited from Shanghai, and 
      the other 29 pairs came from Wenzhou. Maternal blood, cord blood, and meconium 
      specimens were collected in the subject population from Shanghai and analyzed for 
      non-POPs, including mono-2-ethylhexyl phthalate (MEHP), octylphenol (OP) and 
      4-nonylphenol (4-NP). A total of 19 polybrominated diphenyl ethers (PBDEs) 
      congeners, which belong to POPs, were detected in maternal and cord blood 
      specimens from the other 29 pairs. Fetal-maternal ratios (F-M ratios) and 
      regression coefficients were presented to assess potential function of placenta 
      on barricading the mother/fetal transfer of these EDs. Concentrations of the 
      detected non-POPs in cord blood samples were approximately 20% lower than those 
      in maternal blood, and regression coefficients of which were all over 0.80. In 
      contrast, PBDEs levels in cord blood samples were significantly higher than those 
      in maternal blood. MEHP levels in meconium were much higher than those in cord 
      blood samples, and highly correlated. Therefore, observations demonstrated that 
      the placental barrier slightly decreased the fetal exposure to most non-POPs, 
      while PBDEs seemed to be totally transferred across the placenta and finally 
      reached the fetus. For in utero exposure assessment of Di-2-ethylhexyl phthalate 
      (DEHP), MEHP level in meconium may be a useful biomarker.
FAU - Li, Lu-Xi
AU  - Li LX
AD  - Key Laboratory of Public Health Safety, Ministry of Education, School of Public 
      Health, Fudan University, Shanghai, China.
FAU - Chen, Li
AU  - Chen L
FAU - Meng, Xiang-Zhou
AU  - Meng XZ
FAU - Chen, Bing-Heng
AU  - Chen BH
FAU - Chen, Shang-Qin
AU  - Chen SQ
FAU - Zhao, Yan
AU  - Zhao Y
FAU - Zhao, Li-Fang
AU  - Zhao LF
FAU - Liang, Yuan
AU  - Liang Y
FAU - Zhang, Yun-Hui
AU  - Zhang YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130507
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - China
MH  - Endocrine Disruptors/*blood/*pharmacokinetics
MH  - Environmental Pollutants/*blood/*pharmacokinetics
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Exposure
MH  - *Maternal-Fetal Exchange
MH  - Meconium/chemistry
MH  - *Mothers
MH  - Pregnancy
MH  - Regression Analysis
PMC - PMC3646826
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/05/15 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/05/07
CRDT- 2013/05/14 06:00
PHST- 2013/01/23 00:00 [received]
PHST- 2013/03/22 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/05/07 00:00 [pmc-release]
AID - PONE-D-13-03434 [pii]
AID - 10.1371/journal.pone.0062526 [doi]
PST - epublish
SO  - PLoS One. 2013 May 7;8(5):e62526. doi: 10.1371/journal.pone.0062526. Print 2013.