PMID- 23667665
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20240319
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 5
DP  - 2013
TI  - Aberrant functional organization within and between resting-state networks in AD.
PG  - e63727
LID - 10.1371/journal.pone.0063727 [doi]
LID - e63727
AB  - Altered functional characteristics have been reported in amnestic mild cognitive 
      impairment (aMCI) and Alzheimer's disease (AD); nonetheless, comprehensive 
      analyses of the resting-state networks (RSNs) are rare. This study combined 
      multiple imaging modalities to investigate the functional and structural changes 
      within each RSN and between RSNs in aMCI/AD patients. Eight RSNs were identified 
      from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using 
      independent component analysis. We compared functional connectivity (FC) within 
      each RSN and found decreased FC in the several cognitive-related RSNs in AD, 
      including the bilateral precuneus of the precuneus network, the posterior 
      cingulate cortex and left precuneus of the posterior default mode network (DMN), 
      and the left superior parietal lobule of the left frontoparietal network (LFP). 
      We further compared the grey matter volumes and amplitudes of low-frequency 
      fluctuations of these regions and found decreases in these measures in AD. 
      Importantly, we found decreased inter-network connectivity between the visual 
      network and the LFP and between the anterior and posterior DMNs in AD. All 
      indices in aMCI patients were numerically between those of controls and AD 
      patients. These results suggest that the brain networks supporting complex 
      cognitive processes are specifically and progressively impaired over the course 
      of AD, and the FC impairments are present not only within networks but also 
      between networks.
FAU - Song, Jinyu
AU  - Song J
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China.
FAU - Qin, Wen
AU  - Qin W
FAU - Liu, Yong
AU  - Liu Y
FAU - Duan, Yunyun
AU  - Duan Y
FAU - Liu, Jieqiong
AU  - Liu J
FAU - He, Xiaoxi
AU  - He X
FAU - Li, Kuncheng
AU  - Li K
FAU - Zhang, Xinqing
AU  - Zhang X
FAU - Jiang, Tianzi
AU  - Jiang T
FAU - Yu, Chunshui
AU  - Yu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130507
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/pathology/*physiopathology
MH  - Brain Mapping
MH  - Cerebral Cortex/pathology/physiopathology
MH  - Demography
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/pathology/*physiopathology
MH  - Neuropsychological Tests
MH  - Organ Size
MH  - Rest/*physiology
PMC - PMC3647055
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/05/15 06:00
MHDA- 2013/12/18 06:00
PMCR- 2013/05/07
CRDT- 2013/05/14 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2013/04/05 00:00 [accepted]
PHST- 2013/05/14 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2013/05/07 00:00 [pmc-release]
AID - PONE-D-12-29479 [pii]
AID - 10.1371/journal.pone.0063727 [doi]
PST - epublish
SO  - PLoS One. 2013 May 7;8(5):e63727. doi: 10.1371/journal.pone.0063727. Print 2013.