PMID- 23670091
OWN - NLM
STAT- MEDLINE
DCOM- 20140206
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 38
IP  - 8
DP  - 2013 Aug
TI  - (2S)-5, 2', 5'-trihydroxy-7-methoxyflavanone, a natural product from Abacopteris 
      penangiana, presents neuroprotective effects in vitro and in vivo.
PG  - 1686-94
LID - 10.1007/s11064-013-1070-8 [doi]
AB  - The aim of this study was to investigate the neuroprotective effects of (2S)-5, 
      2', 5'-trihydroxy-7-methoxyflavanone (TMF), a natural product from Abacopteris 
      penangiana (Hook.) Ching, in oxidative stress-induced neurodegeneration models in 
      vitro and in vivo. In PC12 cells, preincubation of TMF (3-20 muM) for 24 h 
      decreased the dopamine-induced toxicity and attenuated the redox imbalance in 
      PC12 cells through regulating the ratio of reduced glutathione/oxidized 
      glutathione (GSH/GSSG), which is a sensitive marker of oxidative stress. 
      Additionally, long-term intraperitoneal (i.p.) injection of TMF (4 or 
      8 mg/kg/day) for 2 weeks significantly improved the behavioral performance of 
      D-galactose (D-gal) treated mice in a Morris water maze test. Biochemical 
      analysis revealed that TMF inhibited the activation of AP-1 (activator protein-1) 
      and upregulated the level of BDNF (brain derived neurophic factor) as well as the 
      ratio of GSH/GSSG in the hippocampus of D-gal treated mice. Furthermore, western 
      blotting analysis indicated that TMF increased phosphorylation of cAMP-response 
      element-binding protein (CREB). Therefore, the natural product TMF possessed a 
      potential for the treatment of neurodegenerative diseases.
FAU - Wei, Han
AU  - Wei H
AD  - Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei 
      Province, School of Pharmacy, Tongji Medical College, Huazhong University of 
      Science and Technology, No. 13, Hangkong Road, Wuhan, 430030, China.
FAU - Wu, Guanghua
AU  - Wu G
FAU - Chen, Jinglou
AU  - Chen J
FAU - Zhang, Xuenong
AU  - Zhang X
FAU - Xiong, Chaomei
AU  - Xiong C
FAU - Lei, Yongfang
AU  - Lei Y
FAU - Chen, Wei
AU  - Chen W
FAU - Ruan, Jinlan
AU  - Ruan J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130514
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (5,2',5'-trihydroxy-7-methoxyflavone)
RN  - 0 (Flavones)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - GAN16C9B8O (Glutathione)
RN  - ULW86O013H (Glutathione Disulfide)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Dopamine/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Flavones/isolation & purification/*pharmacology
MH  - Glutathione/metabolism
MH  - Glutathione Disulfide/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - In Vitro Techniques
MH  - Maze Learning/drug effects
MH  - Mice
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuroprotective Agents/isolation & purification/*pharmacology
MH  - PC12 Cells
MH  - Pteridaceae/*chemistry
MH  - Rats
EDAT- 2013/05/15 06:00
MHDA- 2014/02/07 06:00
CRDT- 2013/05/15 06:00
PHST- 2013/03/11 00:00 [received]
PHST- 2013/05/04 00:00 [accepted]
PHST- 2013/05/02 00:00 [revised]
PHST- 2013/05/15 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2014/02/07 06:00 [medline]
AID - 10.1007/s11064-013-1070-8 [doi]
PST - ppublish
SO  - Neurochem Res. 2013 Aug;38(8):1686-94. doi: 10.1007/s11064-013-1070-8. Epub 2013 
      May 14.