PMID- 23670594 OWN - NLM STAT- MEDLINE DCOM- 20160526 LR - 20240109 IS - 1422-0067 (Print) IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 14 IP - 5 DP - 2013 May 13 TI - TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. PG - 10122-42 LID - 10.3390/ijms140510122 [doi] AB - The Trk family of receptors play a wide variety of roles in physiological and disease processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in particular has attracted major attention due to its critical role in signalling for brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4 (NT4). TrkB signalling is indispensable for the survival, development and synaptic plasticity of several subtypes of neurons in the nervous system. Substantial evidence has emerged over the last decade about the involvement of aberrant TrkB signalling and its compromise in various neuropsychiatric and degenerative conditions. Unusual changes in TrkB signalling pathway have also been observed and implicated in a range of cancers. Variations in TrkB pathway have been observed in obesity and hyperphagia related disorders as well. Both BDNF and TrkB have been shown to play critical roles in the survival of retinal ganglion cells in the retina. The ability to specifically modulate TrkB signalling can be critical in various pathological scenarios associated with this pathway. In this review, we discuss the mechanisms underlying TrkB signalling, disease implications and explore plausible ameliorative or preventive approaches. FAU - Gupta, Vivek K AU - Gupta VK AD - Australian School of Advanced Medicine, Macquarie University, F10A, 2 Technology Place, North Ryde, Sydney, NSW 2109, Australia. vivek.gupta@mq.edu.au. FAU - You, Yuyi AU - You Y FAU - Gupta, Veer Bala AU - Gupta VB FAU - Klistorner, Alexander AU - Klistorner A FAU - Graham, Stuart L AU - Graham SL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20130513 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Receptor, trkB) RN - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 11) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/metabolism MH - Humans MH - Mental Disorders/*metabolism/therapy MH - Neoplasms/*metabolism/therapy MH - Neurodegenerative Diseases/*metabolism/therapy MH - Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism MH - Receptor, trkB/*metabolism MH - *Signal Transduction PMC - PMC3676832 EDAT- 2013/05/15 06:00 MHDA- 2013/05/15 06:01 PMCR- 2013/05/01 CRDT- 2013/05/15 06:00 PHST- 2013/03/27 00:00 [received] PHST- 2013/04/27 00:00 [revised] PHST- 2013/04/28 00:00 [accepted] PHST- 2013/05/15 06:00 [entrez] PHST- 2013/05/15 06:00 [pubmed] PHST- 2013/05/15 06:01 [medline] PHST- 2013/05/01 00:00 [pmc-release] AID - ijms140510122 [pii] AID - ijms-14-10122 [pii] AID - 10.3390/ijms140510122 [doi] PST - epublish SO - Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.