PMID- 23671852
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130515
LR  - 20211021
IS  - 2314-6745 (Print)
IS  - 2314-6753 (Electronic)
VI  - 2013
DP  - 2013
TI  - Impact of serum retinol-binding protein 4 levels on regulation of remnant-like 
      particles triglyceride in type 2 diabetes mellitus.
PG  - 143515
LID - 10.1155/2013/143515 [doi]
LID - 143515
AB  - Background. Although retinol-binding protein 4 (RBP4) associates with insulin 
      resistance and remnant-like particles triglyceride (RLP-TG) elevated in the 
      insulin resistant state, few data exist regarding the relationship between RBP4 
      and RLP-TG. Subjects and Methods. The study included 92 Japanese type 2 diabetic 
      mellitus (T2DM) male patients (age 60.5 +/- 13.6 years, body mass index (BMI) 24.7 
      +/- 4.1 kg/m(2), waist circumference (WC) 88.4 +/- 10.7 cm, and HbA1c (NGSP) 7.2 +/- 
      1.9%). Patients on medications affecting insulin sensitivity, including fibrates, 
      biguanides, and thiazolidinedione, were excluded. Visceral fat area (VFA) and 
      subcutaneous fat area (SFA) were measured by computed tomography. Results. RBP4 
      levels showed a significant positive correlation with RLP-TG (r = 0.2544 and P = 
      0.0056), TG (r = 0.1852 and P = 0.041), RLP-TG/TG (r = 0.23765 and P = 0.0241), 
      and age (r = -0.2082 and P = 0.0219), although there was no significant 
      correlation with VFA, SFA, adiponectin levels, or homeostasis model of assessment 
      insulin resistance (HOMA-R). Multiple regression analysis revealed that RBP4 was 
      an independent determinant of RLP-TG (P = 0.0193) but was not a determinant of 
      TG. Conclusions. RBP4 correlates positively with serum RLP-TG independent of fat 
      accumulation in T2DM. RBP4 may regulate remnant metabolism independent of 
      glycemic control in T2DM.
FAU - Yamaaki, Naoto
AU  - Yamaaki N
AD  - Department of Internal Medicine, Graduate School of Medical Science, Kanazawa 
      University, 13-1 Takaramachi, Kanazawa 920-8640, Japan.
FAU - Yagi, Kunimasa
AU  - Yagi K
FAU - Kobayashi, Junji
AU  - Kobayashi J
FAU - Nohara, Atsushi
AU  - Nohara A
FAU - Ito, Naoko
AU  - Ito N
FAU - Asano, Akimichi
AU  - Asano A
FAU - Nakano, Kaoru
AU  - Nakano K
FAU - Liu, Jianhui
AU  - Liu J
FAU - Okamoto, Takuya
AU  - Okamoto T
FAU - Mori, Yukiko
AU  - Mori Y
FAU - Ohbatake, Azusa
AU  - Ohbatake A
FAU - Okazaki, Satoko
AU  - Okazaki S
FAU - Takeda, Yoshiyu
AU  - Takeda Y
FAU - Yamagishi, Masakazu
AU  - Yamagishi M
LA  - eng
PT  - Journal Article
DEP - 20130319
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
PMC - PMC3647570
EDAT- 2013/05/15 06:00
MHDA- 2013/05/15 06:01
PMCR- 2013/03/19
CRDT- 2013/05/15 06:00
PHST- 2012/12/25 00:00 [received]
PHST- 2013/02/12 00:00 [accepted]
PHST- 2013/05/15 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2013/05/15 06:01 [medline]
PHST- 2013/03/19 00:00 [pmc-release]
AID - 10.1155/2013/143515 [doi]
PST - ppublish
SO  - J Diabetes Res. 2013;2013:143515. doi: 10.1155/2013/143515. Epub 2013 Mar 19.