PMID- 23671867
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130515
LR  - 20220408
IS  - 2314-6745 (Print)
IS  - 2314-6753 (Electronic)
VI  - 2013
DP  - 2013
TI  - The Relationship between Type 2 Diabetes Mellitus and Related Thyroid Diseases.
PG  - 390534
LID - 10.1155/2013/390534 [doi]
LID - 390534
AB  - Type 2 diabetes mellitus (T2DM) has an intersecting underlying pathology with 
      thyroid dysfunction. The literature is punctuated with evidence indicating a 
      contribution of abnormalities of thyroid hormones to type 2 DM. The most probable 
      mechanism leading to T2DM in thyroid dysfunction could be attributed to perturbed 
      genetic expression of a constellation of genes along with physiological 
      aberrations leading to impaired glucose utilization and disposal in muscles, 
      overproduction of hepatic glucose output, and enhanced absorption of splanchnic 
      glucose. These factors contribute to insulin resistance. Insulin resistance is 
      also associated with thyroid dysfunction. Hyper- and hypothyroidism have been 
      associated with insulin resistance which has been reported to be the major cause 
      of impaired glucose metabolism in T2DM. The state-of-art evidence suggests a 
      pivotal role of insulin resistance in underlining the relation between T2DM and 
      thyroid dysfunction. A plethora of preclinical, molecular, and clinical studies 
      have evidenced an undeniable role of thyroid malfunctioning as a comorbid 
      disorder of T2DM. It has been investigated that specifically designed thyroid 
      hormone analogues can be looked upon as the potential therapeutic strategies to 
      alleviate diabetes, obesity, and atherosclerosis. These molecules are in final 
      stages of preclinical and clinical evaluation and may pave the way to unveil a 
      distinct class of drugs to treat metabolic disorders.
FAU - Wang, Chaoxun
AU  - Wang C
AD  - Department of Endocrinology, Shanghai Pudong Hospital, Fudan University Pudong 
      Medical Center, 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China.
LA  - eng
PT  - Journal Article
DEP - 20130404
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
PMC - PMC3647563
EDAT- 2013/05/15 06:00
MHDA- 2013/05/15 06:01
PMCR- 2013/04/04
CRDT- 2013/05/15 06:00
PHST- 2013/01/20 00:00 [received]
PHST- 2013/03/15 00:00 [accepted]
PHST- 2013/05/15 06:00 [entrez]
PHST- 2013/05/15 06:00 [pubmed]
PHST- 2013/05/15 06:01 [medline]
PHST- 2013/04/04 00:00 [pmc-release]
AID - 10.1155/2013/390534 [doi]
PST - ppublish
SO  - J Diabetes Res. 2013;2013:390534. doi: 10.1155/2013/390534. Epub 2013 Apr 4.