PMID- 23672276 OWN - NLM STAT- MEDLINE DCOM- 20140724 LR - 20211021 IS - 1473-0790 (Electronic) IS - 1368-5538 (Print) IS - 1368-5538 (Linking) VI - 16 IP - 4 DP - 2013 Dec TI - Association of serum calcium with serum sex steroid hormones in men in NHANES III. PG - 151-8 LID - 10.3109/13685538.2013.772133 [doi] AB - BACKGROUND: Bone is a positive regulator of male fertility, which indicates a link between regulation of bone remodeling and reproduction or more specifically a link between calcium and androgens. This possibly suggests how calcium is linked to prostate cancer development through its link with the reproductive system. We studied serum calcium and sex steroid hormones in the Third National Health and Nutrition Examination Survey (NHANES III). METHODS: Serum calcium and sex steroid hormones were measured for 1262 men in NHANES III. We calculated multivariable-adjusted geometric means of serum concentrations of total and estimated free testosterone and estradiol, androstanediol glucuronide (AAG), and sex hormone binding globulin (SHBG) by categories of calcium (lowest 5% [<1.16 mmol/L], mid 90%, top 5% [>/=1.30 mmol/L]). RESULTS: Levels of total and free testosterone, total estradiol or AAG did not differ across categories of serum calcium. Adjusted SHBG concentrations were 36.4 for the bottom 5%, 34.2 for the mid 90% and 38.9 nmol/L for the top 5% of serum calcium (Ptrend = 0.006), free estradiol levels were 0.88, 0.92 and 0.80 pg/ml (Ptrend = 0.048). CONCLUSIONS: This link between calcium and sex steroid hormones, in particular the U-shaped pattern with SHBG, may, in part, explain why observational studies have found a link between serum calcium and risk of prostate cancer. FAU - Van Hemelrijck, Mieke AU - Van Hemelrijck M AD - Division of Cancer Studies, Cancer Epidemiology Group, School of Medicine, King's College London , London , UK . FAU - Michaelsson, Karl AU - Michaelsson K FAU - Nelson, William G AU - Nelson WG FAU - Kanarek, Norma AU - Kanarek N FAU - Dobs, Adrian AU - Dobs A FAU - Platz, Elizabeth A AU - Platz EA FAU - Rohrmann, Sabine AU - Rohrmann S LA - eng GR - P30 CA006973/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130514 PL - England TA - Aging Male JT - The aging male : the official journal of the International Society for the Study of the Aging Male JID - 9808210 RN - 0 (Gonadal Steroid Hormones) RN - 0 (Sex Hormone-Binding Globulin) RN - SY7Q814VUP (Calcium) SB - IM MH - Bone and Bones/metabolism MH - Calcium/*blood MH - Gonadal Steroid Hormones/*blood MH - Humans MH - Male MH - Middle Aged MH - Nutrition Surveys MH - *Prostatic Neoplasms/epidemiology/metabolism MH - Risk Assessment MH - Sex Hormone-Binding Globulin/metabolism MH - Statistics as Topic PMC - PMC4005327 MID - NIHMS568082 EDAT- 2013/05/16 06:00 MHDA- 2014/07/25 06:00 PMCR- 2014/04/30 CRDT- 2013/05/16 06:00 PHST- 2013/05/16 06:00 [entrez] PHST- 2013/05/16 06:00 [pubmed] PHST- 2014/07/25 06:00 [medline] PHST- 2014/04/30 00:00 [pmc-release] AID - 10.3109/13685538.2013.772133 [doi] PST - ppublish SO - Aging Male. 2013 Dec;16(4):151-8. doi: 10.3109/13685538.2013.772133. Epub 2013 May 14.