PMID- 23673102
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20130515
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 126
IP  - 10
DP  - 2013
TI  - Cytogenetic and molecular aberrations of multiple myeloma patients: a 
      single-center study in Singapore.
PG  - 1872-7
AB  - BACKGROUND: Much is known about the cytogenetic lesions that characterize 
      multiple myeloma (MM) patients from the USA, Europe, and East Asia. However, 
      little has been published about the disease among Southeast Asians. The aim of 
      this study was to determine the chromosomal abnormalities of MM patients in our 
      Singapore population. METHODS: Forty-five newly-diagnosed, morphologically 
      confirmed patients comprising 18 males and 27 females, aged 46 - 84 years (median 
      65 years) were investigated by karyotyping and fluorescence in situ hybridization 
      (FISH). FISH employing standard panel probes and 1p36/1q21 and 6q21/15q22 probes 
      was performed on diagnostic bone marrow samples. RESULTS: Thirty-four cases 
      (75.6%) had karyotypic abnormalities. Including FISH, a total detection rate of 
      91.1% was attained. Numerical and complex structural aberrations were common to 
      both hyperdiploid and non-hyperdiploid patients. Numerical gains of several 
      recurring chromosomes were frequent among hyperdiploid patients while structural 
      rearrangements of several chromosomes including 8q24.1 and 14q32 characterized 
      non-hyperdiploid patients. With FISH, immunoglobulin heavy chain (IGH) gene 
      rearrangements, especially fibroblast growth factor receptor 3 (FGFR3)/IGH and 
      RB1 deletion/monosomy 13 were the most common abnormalities (43.4%). 
      Amplification 1q21 was 10 times more frequent (42.5%) than del(1p36) and 
      del(6q21). CONCLUSIONS: We have successfully reported the comprehensive 
      cytogenetic profiling of a cohort of newly-diagnosed myeloma patients in our 
      population. This study indicates that the genetic and cytogenetic abnormalities, 
      and their frequencies, in our study group are generally similar to other 
      populations.
FAU - Lim, Alvin Soon Tiong
AU  - Lim AS
AD  - Cytogenetics Laboratory, Department of Pathology, Singapore General Hospital, 
      Singapore. alvin.lim.s.t@sgh.com.sg
FAU - Lim, Tse Hui
AU  - Lim TH
FAU - See, Karen Hsu Shien
AU  - See KH
FAU - Ng, Yit Jun
AU  - Ng YJ
FAU - Tan, Yu Min
AU  - Tan YM
FAU - Choo, Natasha Swee Lian
AU  - Choo NS
FAU - Lim, Sherry Xin Er
AU  - Lim SX
FAU - Yee, Yenny
AU  - Yee Y
FAU - Lau, Lai Ching
AU  - Lau LC
FAU - Tien, Sim Leng
AU  - Tien SL
FAU - Sathish, Kumar
AU  - Sathish K
FAU - Tan, Daryl Chen Lung
AU  - Tan DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Retinoblastoma Protein)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Cytogenetics
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Monosomy/genetics
MH  - Multiple Myeloma/*genetics/pathology
MH  - Receptor, Fibroblast Growth Factor, Type 3/genetics
MH  - Retinoblastoma Protein/genetics
MH  - Singapore
EDAT- 2013/05/16 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/05/16 06:00
PHST- 2013/05/16 06:00 [entrez]
PHST- 2013/05/16 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2013;126(10):1872-7.