PMID- 23674053
OWN - NLM
STAT- MEDLINE
DCOM- 20130716
LR  - 20220408
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Linking)
VI  - 14
IP  - 6
DP  - 2013 Jun
TI  - BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative 
      diseases.
PG  - 401-16
LID - 10.1038/nrn3505 [doi]
AB  - Increasing evidence suggests that synaptic dysfunction is a key 
      pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's 
      disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in 
      synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met 
      polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic 
      memory and hippocampal volume - and the technological progress in measuring 
      synaptic changes in humans all pave the way for a 'synaptic repair' therapy for 
      neurodegenerative diseases that targets pathophysiology rather than pathogenesis. 
      This article reviews the key issues in translating BDNF biology into synaptic 
      repair therapies.
FAU - Lu, Bai
AU  - Lu B
AD  - GlaxoSmithKline, R&D China, Shanghai, 201203, China. bai.b.lu@gsk.com
FAU - Nagappan, Guhan
AU  - Nagappan G
FAU - Guan, Xiaoming
AU  - Guan X
FAU - Nathan, Pradeep J
AU  - Nathan PJ
FAU - Wren, Paul
AU  - Wren P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130515
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology/*therapeutic use
MH  - Humans
MH  - Molecular Targeted Therapy/*methods
MH  - Neurodegenerative Diseases/*drug therapy
MH  - Neurogenesis/genetics/*physiology
MH  - Neuronal Plasticity/genetics/*physiology
MH  - Polymorphism, Single Nucleotide/physiology
MH  - Receptor, trkB/agonists/metabolism
MH  - Synapses/*physiology
EDAT- 2013/05/16 06:00
MHDA- 2013/07/17 06:00
CRDT- 2013/05/16 06:00
PHST- 2013/05/16 06:00 [entrez]
PHST- 2013/05/16 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - nrn3505 [pii]
AID - 10.1038/nrn3505 [doi]
PST - ppublish
SO  - Nat Rev Neurosci. 2013 Jun;14(6):401-16. doi: 10.1038/nrn3505. Epub 2013 May 15.