PMID- 23674852
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20220408
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 19
IP  - 16
DP  - 2013 Apr 28
TI  - Human leukocyte antigen DQ2/8 prevalence in non-celiac patients with 
      gastrointestinal diseases.
PG  - 2507-13
LID - 10.3748/wjg.v19.i16.2507 [doi]
AB  - AIM: To investigate the prevalence of human leukocyte antigen (HLA) DQ2/8 alleles 
      in Southern Italians with liver and gastrointestinal (GI) diseases outside of 
      celiac disease. METHODS: HLA DQ2/8 status was assessed in 443 patients from three 
      ambulatory gastroenterology clinics in Southern Italy (University of Federico II, 
      Naples, Loreto Crispi Hospital, Ruggi D'Aragona Hospital, Salerno). Patients were 
      grouped based on disease status [pre-post transplant liver disease, 
      esophageal/gastric organic and functional diseases, irritable bowel syndrome 
      (IBS) and inflammatory bowel disease (IBD)] and DQ2/8 alleles, which correspond 
      to a celiac disease genetic risk gradient. Subject allele frequencies were 
      compared to healthy Italian controls. RESULTS: One hundred and ninety-six out of 
      four hundred and forty-three (44.2%) subjects, median age 56 years and 42.6% 
      female, were DQ2/8 positive. When stratifying by disease we found that 86/188 
      (45.7%) patients with liver disease were HLA DQ2/8 positive, 39/73 (53.4%) with 
      functional upper GI diseases and 19/41 (46.3%) with organic upper GI diseases 
      were positive. Furthermore, 38/105 (36.2%) patients with IBS and 14/36 (38.9%) 
      with IBD were HLA DQ2/8 positive (P = 0.21). Compared to healthy controls those 
      with functional upper GI diseases disorders had a 1.8 times higher odds of DQ2/8 
      positivity. Those with liver disease had 1.3 times the odds, albeit not 
      statistically significant, of DQ2/8 positivity. Both those with IBS and IBD had a 
      lower odds of DQ2/8 positivity compared to healthy controls. CONCLUSION: The 
      proportion of individuals HLA DQ2/8 positive is higher in those with liver/upper 
      functional GI disease and lower in IBS/IBD as compared to general population 
      estimates.
FAU - DiGiacomo, Daniel
AU  - DiGiacomo D
AD  - Gastrointestinal Unit, University Federico II Naples, 80131 Naples, Italy.
FAU - Santonicola, Antonella
AU  - Santonicola A
FAU - Zingone, Fabiana
AU  - Zingone F
FAU - Troncone, Edoardo
AU  - Troncone E
FAU - Caria, Maria Cristina
AU  - Caria MC
FAU - Borgheresi, Patrizia
AU  - Borgheresi P
FAU - Parrilli, Gianpaolo
AU  - Parrilli G
FAU - Ciacci, Carolina
AU  - Ciacci C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gastrointestinal Diseases/*genetics/immunology
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Italy
MH  - Liver Diseases/*genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3646141
OTO - NOTNLM
OT  - Celiac disease
OT  - Gastro-intestinal and liver disease
OT  - Human leukocyte antigen DQ2/8
EDAT- 2013/05/16 06:00
MHDA- 2014/01/01 06:00
PMCR- 2013/04/28
CRDT- 2013/05/16 06:00
PHST- 2012/08/06 00:00 [received]
PHST- 2013/02/05 00:00 [revised]
PHST- 2013/02/07 00:00 [accepted]
PHST- 2013/05/16 06:00 [entrez]
PHST- 2013/05/16 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PHST- 2013/04/28 00:00 [pmc-release]
AID - 10.3748/wjg.v19.i16.2507 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2013 Apr 28;19(16):2507-13. doi: 10.3748/wjg.v19.i16.2507.