PMID- 23675091
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1550-9702 (Print)
IS  - 1555-2810 (Electronic)
IS  - 1550-9702 (Linking)
VI  - 4
IP  - 3
DP  - 2008 Sep
TI  - Increase in Levels of BDNF is Associated with Inflammation and Oxidative Stress 
      during Cardiopulmonary Bypass.
PG  - 204-11
AB  - Cardiopulmonary Bypass (CPB) is thought to generate reactive oxygen species 
      associated with a systemic inflammation and neurotrophins seem to be involved in 
      cardiovascular inflammatory reactions. The aim of this study was to determine the 
      impact of CPB on plasma neurotrophins levels and to appreciate the links existing 
      between inflammation, oxidative stress and neurotrophins. Blood samples were 
      taken from 27 patients undergoing cardiac surgery: before CPB, during ischemia 
      and at reperfusion under CPB. Oxidative stress was evaluated using an Electron 
      Spin Resonance technique by superoxide detection, and antioxidant defences by 
      measurement of Endogenous Peroxidase Activity (EPA). The evolution of two 
      neurotrophins: Brain Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor 
      (NGF) was assessed with an ELISA method. An inflammatory index was determined by 
      a multiplex flow cytometry method. The inflammatory index showed that MCP-1, 
      P-selectin, t-PA and interleukins 6, 8 and 10 levels increased during CPB 
      (p<0.05). Superoxide production and EPA were higher during ischemia and 
      reperfusion than before CPB (p<0.05). BDNF plasma levels were higher at 
      reperfusion (p<0.05). NGF levels did not change. Our study shows an increase of 
      BDNF levels, associated with an inflammatory phenomenon and a redox modification, 
      in the plasma of patients undergoing cardiac surgery under CPB. The role played 
      by this neurotrophin in this complex situation still needs to be elucidated, in 
      particular its cellular origin. It is also necessary to understand whether BDNF 
      has a beneficial or deleterious effect during CPB.
FAU - Amoureux, Sebastien
AU  - Amoureux S
AD  - LPPCE, IFR Sante STIC 100, Facultes de Medecine et de Pharmacie, Dijon, France; ; 
      Departement d'Anesthesie Reanimation, CHRU Le Bocage, Dijon, France;
FAU - Sicard, Pierre
AU  - Sicard P
FAU - Korandji, Claudia
AU  - Korandji C
FAU - Borey, Angelique
AU  - Borey A
FAU - Benkhadra, Salima
AU  - Benkhadra S
FAU - Sequeira-Le Grand, Anabelle
AU  - Sequeira-Le Grand A
FAU - Vergely, Catherine
AU  - Vergely C
FAU - Girard, Claude
AU  - Girard C
FAU - Rochette, Luc
AU  - Rochette L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Biomed Sci
JT  - International journal of biomedical science : IJBS
JID - 101231951
PMC - PMC3614700
OTO - NOTNLM
OT  - BDNF
OT  - cardiac surgery
OT  - cardiopulmonary bypass
OT  - inflammation
OT  - oxidative stress
EDAT- 2008/09/01 00:00
MHDA- 2008/09/01 00:01
PMCR- 2008/09/01
CRDT- 2013/05/16 06:00
PHST- 2008/05/26 00:00 [received]
PHST- 2008/07/01 00:00 [accepted]
PHST- 2013/05/16 06:00 [entrez]
PHST- 2008/09/01 00:00 [pubmed]
PHST- 2008/09/01 00:01 [medline]
PHST- 2008/09/01 00:00 [pmc-release]
AID - IJBS-4-204 [pii]
PST - ppublish
SO  - Int J Biomed Sci. 2008 Sep;4(3):204-11.