PMID- 23675152
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1550-9702 (Print)
IS  - 1555-2810 (Electronic)
IS  - 1550-9702 (Linking)
VI  - 5
IP  - 3
DP  - 2009 Sep
TI  - A Common Polymorphism of Upstream Transcription Factor 1 Gene is associated with 
      Lipid Profile: A Study in Chinese Type 2 Diabetes Families.
PG  - 305-12
AB  - Upstream transcription factor 1 (USF1) is capable of controlling various members 
      in glucose and lipid metabolism pathways. Much evidence suggests that the 
      rs3737787 polymorphism in the USF1 gene may lead to alteration of lipid 
      metabolism. The objective of this study was to test the association between 
      rs3737787 and type 2 diabetes mellitus (T2DM) and its related lipid metabolic 
      traits in the Chinese population. A total of 287 eligible T2DM families were 
      chosen in Beijing. A set of questionnaires was administered to obtain information 
      on demographic characteristics. Physical measurements were recorded. DNA was 
      extracted from blood samples and genotyped using PCR-RFLP method. Statistical 
      analyses including linkage analysis and family-based association test were 
      performed to detect the relationship between rs3737787 and T2DM related traits. 
      In the non-parametric linkage analysis, it was observed that rs3737787 is 
      potentially linked with triglyceride and apolipoprotein E levels, where the 
      logarithm of the odds scores were 0.87 (p=0.02) and 1.96 (p=0.001), respectively. 
      Similar results were obtained in the multi-factorial generalized estimating 
      equation analysis. Using different statistical approaches, in this study, we have 
      confirmed that the single nucleotide polymorphism rs3737787 is related to 
      triglyceride and apolipoprotein E levels in type 2 diabetes mellitus families.
FAU - Song, Yan
AU  - Song Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University, Beijing, China; Key Laboratory of Epidemiology, Ministry of 
      Education, Beijing, China.
FAU - Li, Na
AU  - Li N
FAU - He, Liu
AU  - He L
FAU - Xun, Tang
AU  - Xun T
FAU - Chen, Dafang
AU  - Chen D
FAU - Hu, Yonghua
AU  - Hu Y
LA  - eng
PT  - Case Reports
PL  - United States
TA  - Int J Biomed Sci
JT  - International journal of biomedical science : IJBS
JID - 101231951
PMC - PMC3614780
OTO - NOTNLM
OT  - dyslipidemia
OT  - genetic epidemiology
OT  - single nucleotide polymorphism
OT  - type 2 diabetes mellitus
OT  - upstream transcription factor 1
EDAT- 2009/09/01 00:00
MHDA- 2009/09/01 00:01
PMCR- 2009/09/01
CRDT- 2013/05/16 06:00
PHST- 2009/02/21 00:00 [received]
PHST- 2009/03/18 00:00 [accepted]
PHST- 2013/05/16 06:00 [entrez]
PHST- 2009/09/01 00:00 [pubmed]
PHST- 2009/09/01 00:01 [medline]
PHST- 2009/09/01 00:00 [pmc-release]
AID - IJBS-05-305 [pii]
PST - ppublish
SO  - Int J Biomed Sci. 2009 Sep;5(3):305-12.