PMID- 23675315
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 7
DP  - 2013
TI  - Impact of structural aberrancy of polysialic acid and its synthetic enzyme 
      ST8SIA2 in schizophrenia.
PG  - 61
LID - 10.3389/fncel.2013.00061 [doi]
LID - 61
AB  - Psychiatric disorders are a group of human diseases that impair higher cognitive 
      functions. Whole-genomic analyses have recently identified susceptibility genes 
      for several psychiatric disorders, including schizophrenia. Among the genes 
      reported to be involved in psychiatric disorders, a gene encoding a 
      polysialyltransferase involved in the biosynthesis of polysialic acid (polySia or 
      PSA) on cell surfaces has attracted attention for its potential role in emotion, 
      learning, memory, circadian rhythm, and behaviors. PolySia is a unique polymer 
      that spatio-temporally modifies neural cell adhesion molecule (NCAM) and is 
      predominantly found in embryonic brains, although it persists in areas of the 
      adult brain where neural plasticity, remodeling of neural connections, or neural 
      generation is ongoing, such as the hippocampus, subventricular zone (SVZ), 
      thalamus, prefrontal cortex, and amygdala. PolySia is thought to be involved in 
      the regulation of cell-cell interactions; however, recent evidence suggests that 
      it is also involved in the functional regulation of ion channels and 
      neurologically active molecules, such as Brain-derived neurotrophic factor 
      (BDNF), FGF2, and dopamine (DA) that are deeply involved in psychiatric 
      disorders. In this review, the possible involvement of polysialyltransferase 
      (ST8SIA2/ST8SiaII/STX/Siat8B) and its enzymatic product, polySia, in 
      schizophrenia is discussed.
FAU - Sato, Chihiro
AU  - Sato C
AD  - Laboratory of Animal Cell Function, Bioscience and Biotechnology Center, Nagoya 
      University Nagoya, Japan.
FAU - Kitajima, Ken
AU  - Kitajima K
LA  - eng
PT  - Journal Article
DEP - 20130507
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC3646324
OTO - NOTNLM
OT  - BDNF
OT  - NCAM
OT  - ST8SIA2
OT  - dopamine
OT  - polysialic acid
OT  - polysialyltransferase
OT  - psychiatric disorder
OT  - schizophrenia
EDAT- 2013/05/16 06:00
MHDA- 2013/05/16 06:01
PMCR- 2013/01/01
CRDT- 2013/05/16 06:00
PHST- 2013/01/26 00:00 [received]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/05/16 06:00 [entrez]
PHST- 2013/05/16 06:00 [pubmed]
PHST- 2013/05/16 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2013.00061 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2013 May 7;7:61. doi: 10.3389/fncel.2013.00061. eCollection 
      2013.