PMID- 23676359
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20171116
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 82
IP  - 1
DP  - 2013 Jul
TI  - The prevalence and predictors of androgen deficiency in Taiwanese men with type 2 
      diabetes.
PG  - 124-9
LID - S0090-4295(13)00390-7 [pii]
LID - 10.1016/j.urology.2013.03.023 [doi]
AB  - OBJECTIVE: To evaluate the prevalence and predictors of androgen deficiency (AD) 
      in Taiwanese men with type 2 diabetes mellitus (T2DM). METHODS: A recent 
      hospital-based series of Western populations showed that 30%-50% of men with T2DM 
      have low testosterone, and AD links to DM and obesity bidirectionally. However, 
      data of AD from other ethnicities with character of less obesity are rarely 
      reported. AD was defined as having a total testosterone level less than 
      300 ng/dL. The clinical variables and diabetes-associated complications of the 
      risk of AD were evaluated. RESULTS: Of 766 consecutive subjects (mean age 
      62.2 years, mean body mass index [BMI] 26.0) attending out-patient diabetic 
      clinics, 32.5% have AD. The AD group was older, had higher BMI, waist 
      circumference, higher proportion of metabolic syndrome and stroke, higher levels 
      of triglyceride, high sensitivity C-reactive protein (hsCRP), uric acid, and 
      lower levels of total cholesterol, high-density lipoprotein (HDL), and 
      low-density lipoprotein (LDL) than the normal testosterone group. After age 
      adjustment, AD was positively associated with metabolic syndrome (odds ratio 
      [OR] = 2.142), serum high sensitivity C-reactive protein (OR = 1.120), uric acid 
      (OR = 1.118), BMI (OR = 1.083), waist circumference (OR = 1.038), triglyceride 
      (OR = 1.028), and inversely associated with serum low-density lipoprotein (OR = 
      0.931) and high-density lipoprotein (OR = 0.826) in logistic regression analysis. 
      There were no significant differences in retinopathy, neuropathy, nephropathy, or 
      coronary artery disease between patients with or without AD. CONCLUSION: One 
      third of Taiwanese men with T2DM have AD. The major predictors of AD are linked 
      to obesity, which is a potentially modifiable risk factor, and may represent an 
      important avenue for intervention.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Liu, Rue-Tsuan
AU  - Liu RT
AD  - Chang Gung University College of Medicine, Taiwan.
FAU - Chung, Min-Shen
AU  - Chung MS
FAU - Wang, Pei-Wen
AU  - Wang PW
FAU - Chen, Chung-Dar
AU  - Chen CD
FAU - Lee, Jong-Jer
AU  - Lee JJ
FAU - Lee, Wei-Chia
AU  - Lee WC
FAU - Chancellor, Michael B
AU  - Chancellor MB
FAU - Yang, Kuender D
AU  - Yang KD
FAU - Chuang, Yao-Chi
AU  - Chuang YC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130512
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 268B43MJ25 (Uric Acid)
RN  - 3XMK78S47O (Testosterone)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Humans
MH  - Lipoproteins, HDL/blood
MH  - Lipoproteins, LDL/blood
MH  - Logistic Models
MH  - Male
MH  - Metabolic Syndrome/epidemiology
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prevalence
MH  - Taiwan/epidemiology
MH  - Testosterone/blood/*deficiency
MH  - Triglycerides/blood
MH  - Uric Acid/blood
MH  - Waist Circumference
EDAT- 2013/05/17 06:00
MHDA- 2013/09/17 06:00
CRDT- 2013/05/17 06:00
PHST- 2013/02/05 00:00 [received]
PHST- 2013/03/06 00:00 [revised]
PHST- 2013/03/12 00:00 [accepted]
PHST- 2013/05/17 06:00 [entrez]
PHST- 2013/05/17 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - S0090-4295(13)00390-7 [pii]
AID - 10.1016/j.urology.2013.03.023 [doi]
PST - ppublish
SO  - Urology. 2013 Jul;82(1):124-9. doi: 10.1016/j.urology.2013.03.023. Epub 2013 May 
      12.