PMID- 23680102
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220414
IS  - 1757-6512 (Electronic)
IS  - 1757-6512 (Linking)
VI  - 4
IP  - 2
DP  - 2013 Apr 25
TI  - Regenerating the injured kidney with human umbilical cord mesenchymal stem 
      cell-derived exosomes.
PG  - 39
LID - 10.1186/scrt187 [doi]
AB  - Transplantation of adult stem cells is being used to facilitate repair or 
      regeneration of damaged or diseased tissues. However, in many cases, the 
      therapeutic effects of the injected stem cells are mediated by factors secreted 
      by stem cells and not by differentiation of the transplanted stem cells. Recent 
      reports have identified a class of microvesicles, termed exosomes, released by 
      stem cells that are able to confer therapeutic effects on injured renal and 
      cardiac tissue. In this issue of Stem Cell Research & Therapy, Zhou and 
      colleagues demonstrate the ability of exosomes derived from human umbilical cord 
      mesenchymal stem cells (hucMSCs), but not non-stem cell-derived exosomes, to 
      improve acute kidney injury induced by cisplatin in rats. The authors demonstrate 
      that hucMSC exosomes can reduce cisplatin-mediated renal oxidative stress and 
      apoptosis in vivo and increase renal epithelial cell proliferation in culture. 
      These results suggest that stem cell-derived exosomes, which are easy to isolate 
      and safer to use than the parental stem cells, could have significant clinical 
      utility.
FAU - Dorronsoro, Akaitz
AU  - Dorronsoro A
FAU - Robbins, Paul D
AU  - Robbins PD
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20130425
PL  - England
TA  - Stem Cell Res Ther
JT  - Stem cell research & therapy
JID - 101527581
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
CON - Stem Cell Res Ther. 2013;4(2):34. PMID: 23618405
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cisplatin/*toxicity
MH  - Exosomes/*metabolism
MH  - Female
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology
MH  - Oxidative Stress/*drug effects
MH  - Umbilical Cord/*cytology
PMC - PMC3706756
EDAT- 2013/05/18 06:00
MHDA- 2015/03/31 06:00
PMCR- 2013/04/25
CRDT- 2013/05/18 06:00
PHST- 2013/05/18 06:00 [entrez]
PHST- 2013/05/18 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2013/04/25 00:00 [pmc-release]
AID - scrt187 [pii]
AID - 10.1186/scrt187 [doi]
PST - epublish
SO  - Stem Cell Res Ther. 2013 Apr 25;4(2):39. doi: 10.1186/scrt187.