PMID- 23681157
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 229
IP  - 2
DP  - 2013 Sep
TI  - Fostering itself increases nicotine self-administration in young adult male rats.
PG  - 227-34
LID - 10.1007/s00213-013-3093-x [doi]
AB  - RATIONALE: In gestational exposure studies, a fostered group is frequently used 
      to control for drug-induced maternal effects. However, fostering itself has 
      varying effects depending on the parameters under investigation OBJECTIVES: This 
      study was designed to assess whether maternal behavior contributed to enhanced 
      acquisition (higher number of bar presses compared to controls) of nicotine 
      self-administration (SA) displayed by offspring with gestational nicotine and 
      ethanol (Nic+EtOH) exposure. METHODS: Offspring were exposed to Nic+EtOH 
      throughout full gestation, that is, gestational days (GD) GD2-20 and during 
      postnatal days 2-12 (PN2-12), the rodent third trimester equivalent of human 
      gestation during which rapid brain growth and synaptogenesis occur. Young adult 
      (PN60) male offspring acquired operant nicotine SA, using a model of unlimited 
      (i.e., 23 h) access to nicotine. RESULTS: Gestational drug treatments did not 
      alter litter parameters (body weight, volume distribution, crown-rump length, and 
      brain weight) or postnatal growth of the offspring. Fostering increased locomotor 
      activity to a novel environment on PN45 regardless of gestational treatment 
      group. Surprisingly, fostering per se significantly increased the SA behavior of 
      drug-naive pair-fed controls, so that their drug-taking behavior resembled the 
      enhanced nicotine SA observed in non-fostered offspring exposed to Nic+EtOH 
      during gestation. In contrast, fostering did not change the SA behavior of the 
      Nic+EtOH group. CONCLUSIONS: Fostering is shown to be its own experimental 
      variable, ultimately increasing the acquisition of nicotine SA in control, 
      drug-naive offspring. As such, the current dogma that fostering is required for 
      our gestationally drug-exposed offspring is contraindicated.
FAU - Roguski, Emily E
AU  - Roguski EE
AD  - Department of Pharmacology, University of Tennessee Health Science Center, 115 
      Crowe Research Building, 874 Union Ave., Memphis, TN 38163, USA. 
      eroguski@uthsc.edu
FAU - Chen, Hao
AU  - Chen H
FAU - Sharp, Burt M
AU  - Sharp BM
FAU - Matta, Shannon G
AU  - Matta SG
LA  - eng
GR  - R01 DA015525/DA/NIDA NIH HHS/United States
GR  - DA015525/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130517
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Nicotinic Agonists)
RN  - 3K9958V90M (Ethanol)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Central Nervous System Depressants/*adverse effects
MH  - Ethanol/*adverse effects
MH  - Female
MH  - *Foster Home Care
MH  - Male
MH  - Motor Activity/drug effects
MH  - Nicotine/administration & dosage/adverse effects
MH  - Nicotinic Agonists/*administration & dosage/adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
PMC - PMC3757107
MID - NIHMS481608
EDAT- 2013/05/18 06:00
MHDA- 2014/04/01 06:00
PMCR- 2014/09/01
CRDT- 2013/05/18 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2013/03/29 00:00 [accepted]
PHST- 2013/05/18 06:00 [entrez]
PHST- 2013/05/18 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.1007/s00213-013-3093-x [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2013 Sep;229(2):227-34. doi: 
      10.1007/s00213-013-3093-x. Epub 2013 May 17.