PMID- 23683470
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20220311
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 29
IP  - 7
DP  - 2013 Jul
TI  - Advanced therapies for congenital heart disease: ventricular assist devices and 
      heart transplantation.
PG  - 796-802
LID - S0828-282X(13)00076-7 [pii]
LID - 10.1016/j.cjca.2013.02.008 [doi]
AB  - Improvement in pre-, peri-, and postoperative management of congenital heart 
      disease (CHD) has significantly increased long-term survival in children with 
      CHD. However, there is a subset of patients with CHD who are either poor 
      candidates for surgical palliation or in whom surgical intervention has failed 
      and require advanced cardiac support. Heart transplant (HT) as a therapy for CHD 
      has undergone tremendous evolution. Though transplantation remains the standard 
      of care to improve survival and quality of life when conventional medical and 
      surgical therapies have failed, it remains limited by the scarcity and 
      unpredictability of donor organ availability. As such, the use of ventricular 
      assist devices (VADs) as a bridge to transplant is gaining increasing popularity. 
      Because of improvement in device technology, and reduced rate of VAD-related 
      complications, the use of these devices is expanding to smaller children and more 
      complex congenital anatomy. Challenges with VAD support and HT in the congenital 
      heart population will be addressed in this review with focus on: (1) reasons for 
      VAD implantation; (2) VAD support in Fontan circulation; (3) challenges with 
      human leukocyte antigen (HLA) sensitization in HT; and (4) effect of VAD support 
      on HT in CHD.
CI  - Copyright (c) 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - VanderPluym, Christina
AU  - VanderPluym C
AD  - Department of Cardiology, Children's Hospital Boston, and the Department of 
      Pediatrics, Harvard Medical School, Boston, MA, USA.
FAU - Urschel, Simon
AU  - Urschel S
FAU - Buchholz, Holger
AU  - Buchholz H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130516
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Child
MH  - Fontan Procedure
MH  - HLA Antigens/immunology
MH  - Heart Defects, Congenital/*surgery
MH  - *Heart Transplantation
MH  - *Heart-Assist Devices
MH  - Humans
EDAT- 2013/05/21 06:00
MHDA- 2013/09/06 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/12/20 00:00 [received]
PHST- 2013/02/05 00:00 [revised]
PHST- 2013/02/05 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
AID - S0828-282X(13)00076-7 [pii]
AID - 10.1016/j.cjca.2013.02.008 [doi]
PST - ppublish
SO  - Can J Cardiol. 2013 Jul;29(7):796-802. doi: 10.1016/j.cjca.2013.02.008. Epub 2013 
      May 16.