PMID- 23683513
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20220408
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
VI  - 132
IP  - 1
DP  - 2013 Jul
TI  - Grading local side effects of sublingual immunotherapy for respiratory allergy: 
      speaking the same language.
PG  - 93-8
LID - S0091-6749(13)00528-9 [pii]
LID - 10.1016/j.jaci.2013.03.039 [doi]
AB  - Sublingual immunotherapy (SLIT) is increasingly used worldwide. Despite its 
      safety being well ascertained, there is no universally accepted system to grade 
      and classify its adverse events (AEs). According to the literature, it seems 
      reasonable to classify and grade systemic side effects by using the previously 
      published World Allergy Organization recommendations. On the other hand, local 
      side effects are the most frequent with SLIT, sometimes leading to its 
      discontinuation. Therefore grading of the severity of local side effects was 
      perceived as necessary for the purpose of uniform reporting, classification, and 
      quantification of this aspect. A World Allergy Organization Taskforce, after 
      examining the available literature and the postmarketing surveillance data, 
      proposed a clinically based grading of the severity of local AEs caused by SLIT. 
      The use of the Medical Dictionary for Regulatory Activities nomenclature for AEs 
      was also included in this context. The proposed grading system for SLIT-induced 
      local reactions is expected to improve and harmonize surveillance and reporting 
      of the safety of SLIT.
CI  - Copyright (c) 2013 American Academy of Allergy, Asthma & Immunology. Published by 
      Mosby, Inc. All rights reserved.
FAU - Passalacqua, Giovanni
AU  - Passalacqua G
AD  - Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy. 
      passalacqua@unige.it
FAU - Baena-Cagnani, Carlos E
AU  - Baena-Cagnani CE
FAU - Bousquet, Jean
AU  - Bousquet J
FAU - Canonica, Giorgio Walter
AU  - Canonica GW
FAU - Casale, Thomas B
AU  - Casale TB
FAU - Cox, Linda
AU  - Cox L
FAU - Durham, Stephen R
AU  - Durham SR
FAU - Larenas-Linnemann, Desiree
AU  - Larenas-Linnemann D
FAU - Ledford, Dennis
AU  - Ledford D
FAU - Pawankar, Ruby
AU  - Pawankar R
FAU - Potter, Paul
AU  - Potter P
FAU - Rosario, Nelson
AU  - Rosario N
FAU - Wallace, Dana
AU  - Wallace D
FAU - Lockey, Richard F
AU  - Lockey RF
LA  - eng
PT  - Journal Article
DEP - 20130515
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
SB  - IM
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Desensitization, Immunologic/*adverse effects
MH  - Humans
MH  - Hypersensitivity/*therapy
MH  - Middle Aged
EDAT- 2013/05/21 06:00
MHDA- 2013/09/10 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/12/11 00:00 [received]
PHST- 2013/01/28 00:00 [revised]
PHST- 2013/03/06 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - S0091-6749(13)00528-9 [pii]
AID - 10.1016/j.jaci.2013.03.039 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2013 Jul;132(1):93-8. doi: 10.1016/j.jaci.2013.03.039. 
      Epub 2013 May 15.