PMID- 23684538
OWN - NLM
STAT- MEDLINE
DCOM- 20140530
LR  - 20131021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 210
IP  - 1
DP  - 2013 Nov 30
TI  - Are variations in whole blood BDNF level associated with the BDNF Val66Met 
      polymorphism in patients with first episode depression?
PG  - 102-8
LID - S0165-1781(13)00233-3 [pii]
LID - 10.1016/j.psychres.2013.04.023 [doi]
AB  - Brain derived neurotrophic factor (BDNF) seems to play an important role in the 
      pathophysiology of affective disorders. The current study investigated whether 
      blood level BDNF is correlated with the severity of depressive symptoms and 
      recent (six months prior to onset of depression) experience of stressful life 
      events (SLE) in a cohort of patients with a first depressive episode. 262 
      patients with first episode depression (females 174, males 88, age range 18-70, 
      mean age 41) participated and control sample of 84 participants was included 
      (females 52, males 32, age range 22-70, mean age 42). Symptomatology was rated 
      using Hamilton Rating Scale for Depression (HAMD-17) and Becks Depression 
      Inventory (BDI 21). No differences in whole blood BDNF was seen in relation to 
      the BDNF Val66Met polymorphism and no significant correlations between whole 
      blood BDNF and HAMD-17 or BDI 21 scores were found. No significant associations 
      between the experiences of SLE before onset of depression and BDNF level were 
      observed. Finally, peripheral BDNF differentiated between patients and healthy 
      control persons. In the current sample of first episode depressed patients, the 
      Val66Met polymorphism was not associated with whole blood BDNF and whole blood 
      BNDF level was not associated with the experience of recent SLE.
CI  - (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Vinberg, Maj
AU  - Vinberg M
AD  - Psychiatric Centre Copenhagen, Rigshospitalet, University Hospital of Copenhagen, 
      Blegdamsvej 9, DK-2100 Copenhagen, Denmark. Electronic address: 
      maj.vinberg@regionh.dk.
FAU - Bukh, Jens Drachmann
AU  - Bukh JD
FAU - Bennike, Bente
AU  - Bennike B
FAU - Kessing, Lars V
AU  - Kessing LV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130516
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Cohort Studies
MH  - Depression/*blood/*genetics
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - BDNF Val66Met
OT  - Mood disorder
EDAT- 2013/05/21 06:00
MHDA- 2014/05/31 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/12/08 00:00 [received]
PHST- 2013/04/22 00:00 [revised]
PHST- 2013/04/25 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/05/31 06:00 [medline]
AID - S0165-1781(13)00233-3 [pii]
AID - 10.1016/j.psychres.2013.04.023 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Nov 30;210(1):102-8. doi: 10.1016/j.psychres.2013.04.023. 
      Epub 2013 May 16.