PMID- 23684802
OWN - NLM
STAT- MEDLINE
DCOM- 20140205
LR  - 20220408
IS  - 1873-2763 (Electronic)
IS  - 1873-2763 (Linking)
VI  - 56
IP  - 1
DP  - 2013 Sep
TI  - Excess mortality attributable to hip-fracture: a relative survival analysis.
PG  - 23-9
LID - S8756-3282(13)00188-9 [pii]
LID - 10.1016/j.bone.2013.05.006 [doi]
AB  - INTRODUCTION: Individuals with hip fracture are at substantially increased risk 
      of mortality. The aim of this study was to estimate the excess mortality 
      attributable to hip fracture in elderly men and women. METHODS: The Dubbo 
      Osteoporosis Epidemiology Study was designed as a prospective epidemiologic 
      investigation, in which more than 2000 men and women aged 60+ as of 1989 had been 
      followed for 21 years. During the follow-up period, the incidence of atraumatic 
      hip fractures was ascertained by X-ray reports, and mortality was ascertained by 
      the New South Wales Birth, Death and Marriage Registry. Relative survival ratios 
      were estimated by taking into account the age-and-sex specific expected survival 
      in the general Australian population from 1989 to 2010. RESULTS: During the 
      follow-up period 151 women and 55 men sustained a hip fracture. Death occurred in 
      86 (57%) women and 36 (66%) men. In women, the cumulative relative survival post 
      hip-fracture at 1, 5 and 10 years was 0.83 (95% confidence interval (CI) 
      0.76-0.89), 0.59 (95% CI 0.48-0.68), and 0.31 (95% CI 0.20-0.43), respectively; 
      in men, the corresponding estimates of relative survival were: 0.63 (95% CI 
      0.48-0.75), 0.48 (95% CI 0.32-0.63), and 0.36 (95% CI 0.18-0.56). On average post 
      hip-fracture women died 4 years earlier (median: 4.1, inter-quartile range (IQR) 
      1.7-7.8) and men died 5 years earlier (median = 4.8, IQR 2.4-7.0) than expected. 
      For every six women and for every three men with hip fracture one extra death 
      occurred above that expected in the background population. CONCLUSION: Hip 
      fracture is associated with reduced life expectancy, with men having a greater 
      reduction than women, even after accounting for time-related changes in 
      background mortality in the population. These data underscore that hip fracture 
      is an independent clinical risk factor for mortality.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Frost, Steven A
AU  - Frost SA
AD  - Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St 
      Vincent's Hospital, Australia. s.frost@uws.edu.au
FAU - Nguyen, Nguyen D
AU  - Nguyen ND
FAU - Center, Jacqueline R
AU  - Center JR
FAU - Eisman, John A
AU  - Eisman JA
FAU - Nguyen, Tuan V
AU  - Nguyen TV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130516
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Hip Fractures/*mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New South Wales/epidemiology
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Survival Analysis
OTO - NOTNLM
OT  - Bone mineral density
OT  - Hip fracture
OT  - Mortality
OT  - Osteoporosis
OT  - Relative survival
EDAT- 2013/05/21 06:00
MHDA- 2014/02/06 06:00
CRDT- 2013/05/21 06:00
PHST- 2013/01/14 00:00 [received]
PHST- 2013/04/10 00:00 [revised]
PHST- 2013/05/04 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/02/06 06:00 [medline]
AID - S8756-3282(13)00188-9 [pii]
AID - 10.1016/j.bone.2013.05.006 [doi]
PST - ppublish
SO  - Bone. 2013 Sep;56(1):23-9. doi: 10.1016/j.bone.2013.05.006. Epub 2013 May 16.