PMID- 23684841
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20220318
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1842
IP  - 3
DP  - 2014 Mar
TI  - Sex dimorphism and depot differences in adipose tissue function.
PG  - 377-92
LID - S0925-4439(13)00160-9 [pii]
LID - 10.1016/j.bbadis.2013.05.006 [doi]
AB  - Obesity, characterized by excessive adiposity, is a risk factor for many 
      metabolic pathologies, such as type 2 diabetes mellitus (T2DM). Numerous studies 
      have shown that adipose tissue distribution may be a greater predictor of 
      metabolic health. Upper-body fat (visceral and subcutaneous abdominal) is 
      commonly associated with the unfavorable complications of obesity, while 
      lower-body fat (gluteal-femoral) may be protective. Current research 
      investigations are focused on analyzing the metabolic properties of adipose 
      tissue, in order to better understand the mechanisms that regulate fat 
      distribution in both men and women. This review will highlight the adipose tissue 
      depot- and sex-dependent differences in white adipose tissue function, including 
      adipogenesis, adipose tissue developmental patterning, the storage and release of 
      fatty acids, and secretory function. This article is part of a Special Issue 
      entitled: Modulation of Adipose Tissue in Health and Disease.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - White, Ursula A
AU  - White UA
AD  - Pennington Biomedical Research Center, Louisiana State University System, Baton 
      Rouge, LA, USA.
FAU - Tchoukalova, Yourka D
AU  - Tchoukalova YD
AD  - Pennington Biomedical Research Center, Louisiana State University System, Baton 
      Rouge, LA, USA. Electronic address: Yourka.Tchoukalova@pbrc.edu.
LA  - eng
GR  - R01 DK090607/DK/NIDDK NIH HHS/United States
GR  - DK=090607-02/DK/NIDDK NIH HHS/United States
GR  - DK-090607/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20130516
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
SB  - IM
MH  - Adipogenesis
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Body Composition
MH  - Diabetes Mellitus, Type 2/*metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Obesity/*metabolism/physiopathology
MH  - Sex Characteristics
MH  - Subcutaneous Fat/*metabolism
PMC - PMC3926193
MID - NIHMS481104
OTO - NOTNLM
OT  - Adipogenesis
OT  - Adipokine
OT  - Adipose tissue
OT  - Fat distribution
OT  - Fatty acids
OT  - Lipolysis
EDAT- 2013/05/21 06:00
MHDA- 2014/03/29 06:00
PMCR- 2015/03/01
CRDT- 2013/05/21 06:00
PHST- 2013/02/21 00:00 [received]
PHST- 2013/04/18 00:00 [revised]
PHST- 2013/05/03 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - S0925-4439(13)00160-9 [pii]
AID - 10.1016/j.bbadis.2013.05.006 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2014 Mar;1842(3):377-92. doi: 10.1016/j.bbadis.2013.05.006. 
      Epub 2013 May 16.