PMID- 23685105
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20220321
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 20
IP  - 8
DP  - 2013 Aug
TI  - Relationship between left atrial volume index and cognitive decline in elderly 
      patients with sinus rhythm.
PG  - 1074-8
LID - S0967-5868(13)00006-4 [pii]
LID - 10.1016/j.jocn.2012.10.021 [doi]
AB  - Left atrial (LA) enlargement is a predictor of cardiovascular outcomes such as 
      atrial fibrillation (AF), stroke, and death. The aim of this study was to explore 
      the relationship between LA size and cognitive function in elderly patients 
      without any signs of clinical dementia, AF or previous stroke. We assessed the 
      cognitive status and LA volume (LAV) of 108 consecutive patients (27 males; mean 
      age, 74.8 +/- 6.9 years) with sinus rhythm. Cognitive status was assessed by the 
      Mini Mental State Examination (MMSE). Patients with a MMSE score of </=25 were 
      considered to have cognitive impairment. LAV was measured with two-dimensional 
      echocardiography. LAV index (LAVI) was obtained by indexing LAV to body surface 
      area. Thirty-five patients (32.4%) had cognitive impairment. The patients with 
      cognitive impairment had significantly larger left atria than the patients with 
      normal cognitive function. Receiver operating characteristic analysis revealed a 
      cut-off point of >/= 34 mL/m(2) for LAVI to predict patients with cognitive 
      impairment (sensitivity, 97.1%; specificity, 52.1%; positive predictive value, 
      49.3%; negative predictive value, 97.4%). LAVI >/=34 mL/m(2) was significantly 
      associated with cognitive impairment (p = 0.001, odds ratio = 36.91, 95% 
      confidence interval = 4.8-284.2). Logistic regression analysis revealed that LAVI 
      >/= 34 mL/m(2) and age were independently associated with cognitive impairment. 
      Increased LAVI is associated with cognitive impairment. Assessment of cognitive 
      function may be recommended in elderly patients with enlarged left atria.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Karadag, Berrin
AU  - Karadag B
AD  - Department of Internal Medicine/Endocrinology and Metabolism, Sisli Etfal 
      Teaching and Research Hospital, Istanbul, Turkey.
FAU - Ozyigit, Tolga
AU  - Ozyigit T
FAU - Ozben, Beste
AU  - Ozben B
FAU - Kayaoglu, Semra
AU  - Kayaoglu S
FAU - Altuntas, Yuksel
AU  - Altuntas Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130516
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arrhythmia, Sinus/*physiopathology
MH  - Body Surface Potential Mapping/instrumentation/methods
MH  - Cognition Disorders/*diagnosis
MH  - Echocardiography/instrumentation/*methods
MH  - Female
MH  - Heart Atria/*pathology
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Elderly patients
OT  - Left atrial volume index
OT  - Left atrium
EDAT- 2013/05/21 06:00
MHDA- 2014/01/31 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/06/23 00:00 [received]
PHST- 2012/10/03 00:00 [revised]
PHST- 2012/10/14 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - S0967-5868(13)00006-4 [pii]
AID - 10.1016/j.jocn.2012.10.021 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2013 Aug;20(8):1074-8. doi: 10.1016/j.jocn.2012.10.021. Epub 
      2013 May 16.