PMID- 23685365
OWN - NLM
STAT- MEDLINE
DCOM- 20131230
LR  - 20191210
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 458-460
DP  - 2013 Aug 1
TI  - Exposure to ambient ultrafine particles and urinary 8-hydroxyl-2-deoxyguanosine 
      in children with and without eczema.
PG  - 408-13
LID - S0048-9697(13)00432-4 [pii]
LID - 10.1016/j.scitotenv.2013.04.011 [doi]
AB  - Ambient fine and ultrafine particles (UFPs) in urban air are known to contribute 
      to inflammatory and allergic disease. It has been suggested that oxidative stress 
      is an underlying mechanism for the detrimental health effects. The objective of 
      this study was to investigate the short-term effect of ambient UFPs and 
      particulate polycyclic aromatic hydrocarbons (PAHs) on urinary 
      8-hydroxyl-2-deoxyguanosine (8-OHdG) concentrations in children with and without 
      eczema. Spot urine samples were collected from 84 children twice weekly for 61 
      days and 8-OHdG content was measured. Significant associations were found between 
      the ambient UFPs and particle bound PAHs and increase in urinary 8-OHdG levels. 
      An inter-quartile range (IQR) increase in the UFP concentration in the 24-h (IQR, 
      32,300/m(3)) period preceding urine collection was significantly associated with 
      a 5.7% (95% confidence interval [CI], 0.16-1.27%) increase in the urinary 8-OHdG 
      level children with AD. In children without eczema, such short-term effect of 
      previous day UFPs on urinary 8-OHdG was not observed. There were no significant 
      positive associations between the mass fraction of PMs and urinary 8-OHdG. The 
      results suggest that short-term exposure to ambient UFPs plays a critical role in 
      PM induced oxidative stress in children with eczema.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Song, Sanghwan
AU  - Song S
AD  - Environmental Health Research Division, National Institute of Environmental 
      Research, Incheon, Republic of Korea. sanghwan@korea.kr
FAU - Paek, Domyung
AU  - Paek D
FAU - Park, Chunghee
AU  - Park C
FAU - Lee, Chulwoo
AU  - Lee C
FAU - Lee, Jung-Hyun
AU  - Lee JH
FAU - Yu, Seung-Do
AU  - Yu SD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130515
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Particulate Matter)
RN  - 0 (Polycyclic Aromatic Hydrocarbons)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - AYI8EX34EU (Creatinine)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Child
MH  - Creatinine/urine
MH  - Deoxyguanosine/*analogs & derivatives/urine
MH  - Eczema/*urine
MH  - *Environmental Exposure
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Oxidative Stress/*drug effects
MH  - Particle Size
MH  - Particulate Matter/*toxicity
MH  - Polycyclic Aromatic Hydrocarbons/*toxicity
MH  - Republic of Korea
EDAT- 2013/05/21 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/11/08 00:00 [received]
PHST- 2013/03/23 00:00 [revised]
PHST- 2013/04/04 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - S0048-9697(13)00432-4 [pii]
AID - 10.1016/j.scitotenv.2013.04.011 [doi]
PST - ppublish
SO  - Sci Total Environ. 2013 Aug 1;458-460:408-13. doi: 
      10.1016/j.scitotenv.2013.04.011. Epub 2013 May 15.