PMID- 23685488
OWN - NLM
STAT- MEDLINE
DCOM- 20140102
LR  - 20211021
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 61
IP  - 4
DP  - 2013 Apr
TI  - Spectral domain optical coherence tomography for early detection of retinal 
      alterations in patients using hydroxychloroquine.
PG  - 168-71
LID - 10.4103/0301-4738.112161 [doi]
AB  - OBJECTIVE: To determine whether early toxic effects from hydroxychloroquine (HCQ) 
      could be detected by spectral-domain optical coherence tomography (SD-OCT) before 
      symtomatic visual loss occured. MATERIALS AND METHODS: Fifteen subjects with a 
      history of the chronic use of hydroxychloroquine monotherapy for less than five 
      years without fundus changes (group 1) and 15 visually normal healthy subjects 
      (group 2) were enrolled in this study. All participants underwent systemic and 
      ocular examination, visual field testing, and macular scan imaging using SD-OCT. 
      RESULTS: There were no significant differences in sex and ages between the groups 
      (P > 0.05). Mean duration of HCQ usage in group 1 was 2.5 +/- 1.34 (range:1-5) 
      years. Visual field testing with central 10-2 threshold program was normal in all 
      subjects. Inner retinal thickness in parafoveal and perifoveal area were found to 
      be significantly lower in group 1 compared to group 2 (P < 0.01 for perifoveal, P 
      < 0.05 for parafoveal retinal measurements). However, significant thinning was 
      demonstrated only in full retinal thickness of perifoveal area in group 1 
      compared to group 2 (P: 0.013). Parafoveal and perifoveal inner retinal thickness 
      measurements of inferior quadrants were significantly reduced in group 1 compared 
      to group 2 (P < 0.01). CONCLUSION: Significant thinning of inner retinal layer 
      especially in parafoveal and perifoveal areas in the absence of clinical fundus 
      changes was observed in our study. We consider that SD-OCT may determine when 
      inner retinal thinning starts in these patients and may contribute a quantitative 
      approach to the early diagnosis and progression of retinal changes.
FAU - Ulviye, Yigit
AU  - Ulviye Y
AD  - Department of Ophthalmology, Bakirkoy Dr. Sadi Konuk Education and Research 
      Hospital, Istanbul, Turkey.
FAU - Betul, Tugcu
AU  - Betul T
FAU - Nur, Tarakcioglu Hatice
AU  - Nur TH
FAU - Selda, Celik
AU  - Selda C
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
RN  - 0 (Antirheumatic Agents)
RN  - 4QWG6N8QKH (Hydroxychloroquine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antirheumatic Agents/adverse effects
MH  - Drug Monitoring/*methods
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Hydroxychloroquine/*adverse effects
MH  - Lupus Erythematosus, Systemic/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Retina/pathology
MH  - Retinal Diseases/*chemically induced/*pathology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC3714954
COIS- Conflict of Interest: No.
EDAT- 2013/05/21 06:00
MHDA- 2014/01/03 06:00
PMCR- 2013/04/01
CRDT- 2013/05/21 06:00
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/01/03 06:00 [medline]
PHST- 2013/04/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2013_61_4_168_112161 [pii]
AID - IJO-61-168 [pii]
AID - 10.4103/0301-4738.112161 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2013 Apr;61(4):168-71. doi: 10.4103/0301-4738.112161.