PMID- 23686130
OWN - NLM
STAT- MEDLINE
DCOM- 20141231
LR  - 20221123
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 40
IP  - 3
DP  - 2014 May
TI  - Improvements in negative symptoms and functional outcome after a new generation 
      cognitive remediation program: a randomized controlled trial.
PG  - 707-15
LID - 10.1093/schbul/sbt057 [doi]
AB  - Cognitive remediation improves cognition in patients with schizophrenia, but its 
      effect on other relevant factors such as negative symptoms and functional outcome 
      has not been extensively studied. In this hospital-based study, 84 inpatients 
      with chronic schizophrenia were recruited from Alava Hospital (Spain). All of the 
      subjects underwent a baseline and a 3-month assessment that examined 
      neurocognition, clinical symptoms, insight, and functional outcome according to 
      the Global Assessment of Functioning (GAF) scale and Disability Assessment 
      Schedule from World Health Organization (DAS-WHO). In addition to receiving 
      standard treatment, patients were randomly assigned either to receive 
      neuropsychological rehabilitation (REHACOP) or to a control group. REHACOP is an 
      integrative program that taps all basic cognitive functions. The program included 
      experts' latest suggestions about positive feedback and activities of daily 
      living in the patients' environment. The REHACOP group showed significantly 
      greater improvements at 3 months in the areas of neurocognition, negative 
      symptoms, disorganization, and emotional distress compared with the control group 
      (Cohen's effect size for these changes ranged from d = 0.47 for emotional 
      distress to d = 0.58 for disorganization symptoms). The REHACOP group also 
      improved significantly in both the GAF (d = 0.61) and DAS-WHO total scores (d = 
      0.57). Specifically, the patients showed significant improvement in vocational 
      outcomes (d = 0.47), family contact (d = 0.50), and social competence (d = 0.56). 
      In conclusion, neuropsychological rehabilitation may be useful for the reduction 
      of negative symptoms and functional disability in schizophrenia. These findings 
      support the integration of neuropsychological rehabilitation into standard 
      treatment programs for patients with schizophrenia.
FAU - Sanchez, Pedro
AU  - Sanchez P
AD  - *To whom correspondence should be addressed; tel: 34 944139000 (ext 2702), fax: 
      34 944139089, e-mail: nojeda@deusto.es.
FAU - Pena, Javier
AU  - Pena J
FAU - Bengoetxea, Eneritz
AU  - Bengoetxea E
FAU - Ojeda, Natalia
AU  - Ojeda N
FAU - Elizagarate, Edorta
AU  - Elizagarate E
FAU - Ezcurra, Jesus
AU  - Ezcurra J
FAU - Gutierrez, Miguel
AU  - Gutierrez M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130518
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Cognition Disorders/psychology/*rehabilitation
MH  - Cognitive Behavioral Therapy/*methods
MH  - Feedback, Psychological
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Schizophrenia/*rehabilitation
MH  - *Schizophrenic Psychology
MH  - Spain
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3984510
OTO - NOTNLM
OT  - REHACOP
OT  - cognitive rehabilitation
OT  - functional outcome
OT  - negative symptoms
OT  - schizophrenia
EDAT- 2013/05/21 06:00
MHDA- 2015/01/01 06:00
PMCR- 2015/05/01
CRDT- 2013/05/21 06:00
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2015/01/01 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - sbt057 [pii]
AID - 10.1093/schbul/sbt057 [doi]
PST - ppublish
SO  - Schizophr Bull. 2014 May;40(3):707-15. doi: 10.1093/schbul/sbt057. Epub 2013 May 
      18.