PMID- 23686476
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20220318
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Oct
TI  - Prognostic significance of Beclin-1 expression in laryngeal squamous cell 
      carcinoma.
PG  - 771-7
LID - 10.1007/s12253-013-9642-0 [doi]
AB  - Beclin-1 plays a critical role in the regulation of autophagy, apoptosis, 
      differentiation and the development and progression of cancer. The aim of the 
      present investigation was to analyze the Beclin-1 protein expression and to 
      assess its prognostic significance in tissue of laryngeal squamous cell carcinoma 
      (LSCC). Beclin-1 protein expression in 82 primary laryngeal squamous cell 
      carcinoma and 40 paracarcinoma non-tumor tissue samples was analyzed by 
      immunohistochemistry and correlated with clinicopathological parameters and 
      patients' outcome. The expression of Beclin-1 in tumor tissues was significantly 
      lower than that in non-tumor tissues (P = 0.035). Reduced Beclin-1 expression was 
      significantly correlated with lymph node metastases (P = 0.021). Kaplan-Meier 
      survival estimates showed a significant correlation between Beclin-1 expression 
      and patient's survival rate (log-rank P < 0.05). Multivariate Cox proportional 
      hazards model analysis confirmed that lymph node metastases (P = 0.048) and 
      Beclin-1 expression (P = 0.029) were statistically significant, independent 
      prognostic factors for LSCC. Our findings suggested that decreased Beclin-1 
      expression and lymph node metastases, as examined by immunohistochemistry, are 
      both independent biomarker for poor prognosis of patients with LSCC.
FAU - Huang, Li
AU  - Huang L
AD  - Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan 
      University, 37, Guoxue Lane, Chengdu, 610041, China.
FAU - Wang, Shuang
AU  - Wang S
FAU - Li, Shi-Sheng
AU  - Li SS
FAU - Yang, Xin-Ming
AU  - Yang XM
LA  - eng
PT  - Journal Article
DEP - 20130519
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (BECN1 protein, human)
RN  - 0 (Beclin-1)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis Regulatory Proteins/*biosynthesis/metabolism
MH  - Beclin-1
MH  - Carcinoma, Squamous Cell/*metabolism/*pathology
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/*pathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/*pathology
MH  - Male
MH  - Membrane Proteins/*biosynthesis/metabolism
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2013/05/21 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2013/04/11 00:00 [accepted]
PHST- 2013/05/21 06:00 [entrez]
PHST- 2013/05/21 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - 10.1007/s12253-013-9642-0 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2013 Oct;19(4):771-7. doi: 10.1007/s12253-013-9642-0. Epub 2013 
      May 19.